Antigen sampling by mucosal dendritic cells
Antigen sampling by mucosal dendritic cells
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DOI：
10.1016/j.molmed.2005.07.001
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发表时间：
2005-09-01
影响因子：
13.6
通讯作者：
Ricciardi-Castagnoli, P
中科院分区：
文献类型：
--
作者：
Foti, M;Ricciardi-Castagnoli, P
粘膜免疫系统是抵御细菌和病毒感染的第一道防线，对维持粘膜稳态至关重要。在肠道中，粘膜树突状细胞为抗原摄取上皮细胞提供了另一种途径，从而启动抗原特异性免疫反应。最近有研究表明，小肠固有层树突状细胞通过上皮树突的形成，通过依赖于趋化因子受体CX3CR1表达的机制，积极地对肠道细菌进行采样。
The mucosal immune system is the first line of defence against bacterial and viral infections and is crucial in maintaining mucosal homeostasis. In the gut, mucosal dendritic cells offer an alternative pathway to epithelial cells for antigen uptake, to initiate antigen-specific immune responses. It has recently been shown that lamina propria dendritic cells of the small intestine actively sample gut bacteria through the formation of transepithelial dendrites by a mechanism that is dependent on the expression of the chemokine receptor CX3CR1.