MORPHOMETRY OF PULMONARY-ARTERIES FROM ANGIOGRAMS IN CHRONIC OBSTRUCTIVE LUNG-DISEASE
MORPHOMETRY OF PULMONARY-ARTERIES FROM ANGIOGRAMS IN CHRONIC OBSTRUCTIVE LUNG-DISEASE
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DOI：
10.1136/thx.36.5.360
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发表时间：
1981-01-01
期刊：
影响因子：
10
通讯作者：
THOMAS, M
中科院分区：
文献类型：
--
作者：
HORSFIELD, K;THOMAS, M
描述了基于斯特拉勒阶的形态测量技术在肺血管造影研究中的应用。当肺动脉树按照Strahler's方法排序时，外周分支具有最低顺序，而主肺动脉具有最高顺序。然后可以确定每个等级的血管平均直径。对 16 名患者进行了肺血管造影，其中 10 名患有慢性阻塞性肺病 (COLD)，另外 6 名血管造影正常。在直径为 1 毫米或更大的血管中发现了六级分支，并且对数平均直径与正常血管造影的级数的关系图呈线性。 COLD 患者的 2、3 和 4 阶平均直径（直径 2-7 mm）显着减小（P < 0.01），并且对数平均直径与阶次图呈上凹状。当 TLC（肺总量）升高时，这些变化比正常时更加明显。病理学进展较严重（通过放射学变化判断）的肺部区域的血管直径图显示，中间顺序甚至有更大的减少。这些变化可能是肺气肿病变中血管拉伸和毛细血管床损失导致血流量减少的结果。
The application of morphometric techniques based on Strahler orders to the study of pulmonary angiograms is described. When the pulmonary arterial tree is ordered by Strahler''s method, peripheral branches have the lowest orders, and the main pulmonary artery the highest order. The mean diameter of vessels in each order can then be determined. Pulmonary angiograms were obtained from 16 patients, 10 of whom had chronic obstructive lung disease (COLD), the other 6 having normal angiograms. Six orders of branching were found in vessels of 1 mm diameter or greater, and a plot of log mean diameter vs. order from the normal angiograms was linear. The mean diameters of orders 2, 3 and 4 (diameter 2-7 mm) from COLD patients were significantly reduced (P < 0.01) and the log mean diameter vs. order plot was concave upwards. These changes were more marked when TLC [total lung capacity] was raised than when it was normal. Plots of diameters of vessels from zones of the lung in which the pathology was well advanced (as judged by radiological changes) showed even greater reduction in the middle orders. These changes are probably the result of stretching of vessels in emphysematous lesions and diminution of blood flow from loss of capillary bed.