Evaluation of the developmental toxicity of diallyl phthalate administered orally to rats.
Evaluation of the developmental toxicity of diallyl phthalate administered orally to rats.
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DOI：
10.1016/j.fct.2008.02.012
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发表时间：
2008-06
期刊：
影响因子：
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通讯作者：
A. Saillenfait;F. Gallissot;J. Sabaté
中科院分区：
文献类型：
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作者：
A. Saillenfait;F. Gallissot;J. Sabaté
本研究旨在评价邻苯二甲酸二烯丙酯（DAP）对大鼠的发育毒性。妊娠Sprague-Dawley大鼠在妊娠第6 - 20天（GD）通过灌胃（5 ml/kg）给予0（橄榄油）、100、150、200和250 mg/kg/天剂量的DAP。尸检时的大体检查显示，150 mg/kg/天或更高剂量组母鼠出现肝脏病变。此外，在200和250 mg/kg/天剂量下，母体体重增量和摄食量显著降低。在任何剂量下，吸收或畸形的发生率均未显著增加。在200和250 mg/kg/天剂量下，胎仔体重显著降低。在250 mg/kg/天剂量下，骨骼变异胎仔的发生率显著增加。还观察到某些骨骼（即前肢和后肢趾骨、跖骨和尾椎）骨化迟缓。在100和150 mg/kg/天剂量下未发现发育毒性迹象。因此，DAP在也产生母体效应的剂量下引起胎儿毒性，但无胚胎致死性或致畸性。
The objective of this study was to evaluate the developmental toxic potential of diallyl phthalate (DAP) in rats. Pregnant Sprague-Dawley rats were given DAP at doses of 0 (olive oil), 100, 150, 200, and 250mg/kg/day, by gavage (5ml/kg), on Gestational Days (GD) 6 through 20. Gross examination at necropsy revealed liver lesions in dams given 150mg/kg/day or higher doses. In addition, maternal weight gain and food consumption were significantly reduced at 200 and 250mg/kg/day. There was no significant increase in the incidence of resorptions, or malformations, at any dose. Fetal body weight was significantly reduced at 200 and 250mg/kg/day. There was a significant increase in the incidence of fetuses with skeletal variations at 250mg/kg/day. Retarded ossification of certain bones (i.e. forelimb and hindlimb phalanges, metatarsals, and caudal vertebrae) was also observed. There was no sign of developmental toxicity at 100 and 150mg/kg/day. Thus, DAP caused fetal toxicity at doses which also produced maternal effects, but no embryolethality or teratogenicity.