Exploring semantic memory by investigating buildup and release of proactive interference in healthy older adults and individuals with dementia of the Alzheimer type.
Exploring semantic memory by investigating buildup and release of proactive interference in healthy older adults and individuals with dementia of the Alzheimer type.
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通过研究健康老年人和阿尔茨海默型痴呆症患者主动干扰的积累和释放来探索语义记忆。
DOI：
10.1017/s1355617703960024
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Faust,MarkE
中科院分区：
文献类型：
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作者：
Multhaup,KristiS;Balota,DavidA;Faust,MarkE
关于阿尔茨海默型痴呆（DAT）的语义记忆完整性存在争议。一种观点认为，DAT与语义记忆的崩溃有关；另一种观点认为，DAT主要与保留的语义记忆和检索的中断有关。经典的主动干扰释放（RPI）范式被用来阐明这一争论。早期DAT患者（n = 36）和健康老年人对照（n = 45）参加了RPI范式。每个试验都是一个布朗-彼得森任务，参与者阅读三个单词列表，数（0,3,6或9秒），然后回忆单词。两组均表现出明显的主动干扰（PI），但DAT组PI的大小明显较小。两组在PI上的差异可能是由于DAT组的遗忘速度更快。两组均表现出显著的RPI，当RPI在PI水平上被考虑时，没有组间大小差异。两组在前表入侵中均表现出PI和RPI。DAT组基于语义类别的PI的显著积累和释放表明，至少在早期DAT个体中，主要保留了语义记忆活动。（植物学报，2003,9,830-838 .）
There is debate regarding the integrity of semantic memory in dementia of the Alzheimer type (DAT). One view argues that DAT is associated with a breakdown in semantic memory; the other argues that DAT is associated with predominantly preserved semantic memory and a breakdown in retrieval. The classic release from proactive interference (RPI) paradigm was used to shed light on this debate. Individuals with early-stage DAT (n = 36) and healthy older adult controls (n = 45) participated in an RPI paradigm. Each trial was a Brown–Peterson task in which participants read three-word lists, counted (for 0, 3, 6, or 9 s), and recalled the words. Both groups showed significant proactive interference (PI), but the size of the PI was significantly smaller in the DAT group. The group difference in PI may be due to the faster forgetting rate in the DAT group. Both groups showed significant RPI and there was no group difference in size when RPI was considered in terms of PI levels. Both groups showed PI and RPI in prior list intrusions. The DAT group's significant buildup and release of PI based on semantic categories suggest predominantly preserved semantic memory activity, at least, in early-stage DAT individuals. (JINS, 2003, 9, 830–838.)