Point pattern analysis of the spatial proximity of residences prior to diagnosis of persons with Hodgkin's disease.
Point pattern analysis of the spatial proximity of residences prior to diagnosis of persons with Hodgkin's disease.
复制标题
在诊断霍奇金病患者之前对住宅空间邻近性进行点模式分析。
DOI：
10.1093/oxfordjournals.aje.a115789
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发表时间：
1990
影响因子：
5
通讯作者：
Davis,S
中科院分区：
文献类型：
--
作者：
Ross,A;Davis,S
有一些证据表明霍奇金病的病因包括传染性成分。调查这种可能性的一种方法是对该疾病发病率的地理和时间变化进行正式评估。本研究旨在更好地评估霍奇金病患者诊断前的居住时空模式。终生居住史是从 1974 年至 1982 年间在华盛顿州西北部的特定人群中诊断出的 279 例霍奇金病病例获得的，并且根据年龄、性别和社会经济地位对病例进行了类似数量的匹配。修改了点模式分析方法，以便在这种情况下使用，以将案例住宅的空间接近度与在案例和对照住宅的空间模式之间没有差异的零假设下预期的空间接近度进行比较。分析适用于先验指定的居住时间分组，假设 1) 无指定潜伏期，2) 四种不同的 5 年潜伏期，以及 3) 三种暴露年龄间隔。假设没有潜伏期，没有证据表明病例居住地的聚集程度比偶然预期的要多或少。假设诊断前的潜伏间隔长达 15 年，病例居住地的聚集程度低于预期，特别是在 40 岁后患霍奇金病的患者中。相比之下，有暗示性证据表明，40 岁后被诊断患有霍奇金病的人在幼儿和青少年时期的居住距离比预期的要近。这些结果说明需要将此类分析集中在预先定义的特定时间间隔上，以最有可能代表最有可能代表病因学相关性的时期。在某种程度上，这些发现并不是该方法本身的某些未知工件的结果，它们可能有助于将更多的注意力集中在儿童环境上，作为该疾病病因学中一个特别重要的时期。此外，所采用的分析方法可能有助于在其他病因学环境中使用基于人群的数据来识别时空聚类
There is some evidence to suggest that the etiology of Hodgkin's disease includes an infectious component One approach to investigating this possibility is a formal assessment of the geographic and temporal variation in the incidence of the disease. The present study was designed to better evaluate space-time patterns of residence prior to diagnosis of persons with Hodgkln's disease. Lifetime residential histories were obtained from 279 incident cases of Hodgkin's disease diagnosed between 1974 and 1982 in a defined population in northwestern Washington State, and a similar number of population controls matched to the cases by age, sex, and socioeconomic status. A method of point pattern analysis was modified for use in this context to compare the spatial proximity of case residences to that expected under the null assumption of no difference between the spatial pattern of case and control residences. Analyses were applied within temporal groupings of residences specified a priori assuming 1) no specified latency, 2) four different 5-year latent intervals, and 3) three age at exposure intervals. Assuming no latency, there is no evidence that case residences are more or less clustered than would be expected by chance. Assuming latent intervals of up to 15 years prior to diagnosis, case residences are less clustered than expected, particularly among those who developed Hodgkin's disease after the age of 40 years. In contrast, there is suggestive evidence that persons diagnosed with Hodgkin's disease after age 40 years lived closer together than expected as young children and teenagers. These results illustrate the need to focus such analyses on specific time intervals defined a priori to most likely represent periods of greatest etiologic relevance. To the extent that these findings are not the result of some unknown artifact of the method itself, they may serve to focus additional attention on childhood environment as a particularly important period in the etiology of this disease. Furthermore, the analytic method employed may be useful in identifying space-time clustering using population-based data in other etiologic settings