CLINICAL AND SEROLOGIC RESPONSES OF VOLUNTEERS INFECTED WITH PHLEBOTOMUS FEVER VIRUS (SICILIAN TYPE)
CLINICAL AND SEROLOGIC RESPONSES OF VOLUNTEERS INFECTED WITH PHLEBOTOMUS FEVER VIRUS (SICILIAN TYPE)
复制标题
DOI：
10.4269/ajtmh.1976.25.456
复制
发表时间：
1976-01-01
影响因子：
3.3
通讯作者：
TESH, RB
中科院分区：
文献类型：
--
作者：
BARTELLONI, PJ;TESH, RB
志愿者(20名)接种了不同剂量的含有白纹伊蚊热病毒(西西里型)的人血清，以确定他们的临床和血清学反应以及该病毒的人类半数感染量。所有感染者均出现发热，持续时间为6~74h。沙蝇热期间最常见的症状是头痛、食欲不振、肌痛、畏光、腰背和眼眶后疼痛。感染者出现明显的白细胞减少，其特征是最初的淋巴细胞减少，随后是长期的中性粒细胞减少。在恢复期血清中几乎没有检测到补体结合抗体，但大多数受试者的血凝抑制抗体显着升高。所有感染者都产生了滴度在1：40-1：2560之间的特异性中和抗体。在3种血清学试验中，空斑减数中和法对白纹伊蚊病毒抗体的检测最为敏感。
Volunteers (20) were inoculated with various doses of human serum containing Phlebotomus fever virus (Sicilian type) to determine their clinical and serologic responses and the human median infectious dose of the virus. All infected subjects developed fever which varied from 6-74 h. The most common symptoms during sandfly fever were headache, anorexia, myalgia, photophobia, low back and retro-orbital pain. Infected individuals developed a marked leukopenia characterized by an initial lymphopenia followed by protracted neutropenia. Little complement fixing antibody was detected in convalescent sera but most subjects developed significant rises in hemagglutination inhibiting antibodies. All infected subjects developed specific neutralizing antibodies with titers ranging from 1:40-1:2560. Of the 3 serologic tests performed, the plaque reduction neutralization method appeared the most sensitive for detecting antibodies to Phlebotomus fever viruses.