Association of MTHFR gene polymorphisms with pancreatic cancer: meta-analysis of 17 case-control studies
Association of MTHFR gene polymorphisms with pancreatic cancer: meta-analysis of 17 case-control studies
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MTHFR 基因多态性与胰腺癌的关联：17 项病例对照研究的荟萃分析
DOI：
10.1007/s10147-019-01571-2
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发表时间：
2020
影响因子：
3.3
通讯作者：
Liu Wanyang
中科院分区：
文献类型：
--
作者：
Nie Fangfang;Yu Mingli;Zhang Kaili;Yang Luping;Zhang Qian;Liu Shan;Liu Mengwei;Shang Mengke;Zeng Fanxin;Liu Wanyang
研究背景胰腺癌（PC）是一种严重的恶性肿瘤，5年生存率较低。多项研究报道了亚甲基四氢叶酸还原酶 (MTHFR) 基因多态性与 PC 之间的关系。然而，结果存在争议。因此，我们进行了荟萃分析来总结MTHFR基因和PC的可用数据。方法我们检索了2019年7月之前的PubMed、Embase、Web of Science、万方、CNKI数据库。使用RevMan 5.3和STATA 12.0软件对数据进行分析。使用比值比 (OR) 和 95% 置信区间 (CI) 来评估关联的强度。本研究进行了亚组分析、敏感性分析和发表偏倚评估。 结果 10 篇文章，17 篇报告（C677T 10 篇，A1298C 7 篇）符合荟萃分析条件（C677T 1864 例病例和 3165 例对照，A1298C 1488 例病例和 1946 例对照）。我们的荟萃分析发现，C677T 在三种遗传模型中与 PC 相关（等位基因模型：OR = 1.24，95% CI：1.00–1.53，P= 0.047；隐性模型：OR = 1.39，95% CI：1.04–1.86，P= 0.027；纯合模型： OR = 1.60, 95% CI: 1.04–2.45,P= 0.034)。在根据种族、对照来源和基因分型方法进行的分层分析中，在基因分型方法亚组中观察到显着相关性。对于A1298C多态性，在所有遗传模型下，无论是总体分析还是亚组分析均未观察到显着的关联。结论MTHFR基因C677T而不是A1298C多态性可能与PC相关。应进行更大样本量的研究来发现 MTHFR 基因与 PC 之间的关联。
BackgroundPancreatic cancer (PC) is a seriously malignant tumor with a low 5-year survival rate. The relationship between methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms and PC has been reported by several studies. However, the results were controversial. Thus, we conducted a meta-analysis to summarize available data onMTHFRgene and PC.MethodsWe searched PubMed, Embase, Web of Science, Wanfang, CNKI databases prior to July 2019. Data were analyzed by RevMan 5.3 and STATA 12.0 software. Odds ratio (OR) and 95% confidence interval (CI) were used to evaluate the strength of the association. Subgroup analysis, sensitivity analysis and assessment of publication bias were performed in this study.ResultsTen articles with 17 reports (10 for C677T, 7 for A1298C) were eligible for inclusion in the meta-analysis (1864 cases and 3165 controls for C677T, and 1488 cases and 1946 controls for A1298C). Our meta-analysis detected that C677T was associated with PC for three genetic models (allele model: OR = 1.24, 95% CI: 1.00–1.53,P= 0.047; recessive model: OR = 1.39, 95% CI: 1.04–1.86,P= 0.027; homozygous model: OR = 1.60, 95% CI: 1.04–2.45,P= 0.034). In the stratified analyses according to ethnicity, source of controls and genotyping method, significant association was observed in genotyping method subgroup. For the A1298C polymorphism, no significant association was observed either in overall analysis or in subgroup analysis under all genetic models.ConclusionsMTHFRgene C677T rather than A1298C polymorphism may be associated with PC. Larger sample size studies should be performed to find the association betweenMTHFRgene and PC.