Endplate degeneration may be the origination of the vacuum phenomenon in intervertebral discs
Endplate degeneration may be the origination of the vacuum phenomenon in intervertebral discs
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DOI：
10.1016/j.mehy.2010.02.012
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发表时间：
2010-08-01
影响因子：
4.7
通讯作者：
Chen, Qi-Xin
中科院分区：
文献类型：
--
作者：
Li, Fang-Cai;Zhang, Ning;Chen, Qi-Xin
椎管内真空现象(VP)通常与退行性腰椎间盘疾病有关，可能与下腰痛有关。关于VP发病机制的各种理论已经提出，但这些理论没有经过严格的检验，仍然是假设的。在这篇文章中，我们回顾了终板退变在VP发病机制中的可能作用，并讨论了几种可能与之相关的途径。由于终板钙化和细胞因子的激活，阻断了营养物质在椎间盘中的运输途径，导致代谢失衡，基质结构蛋白合成减少。促进基质分解，导致基质数量减少，改变了椎间盘的应力分布。结果，椎间盘的结构变得越来越不稳定。当发生压缩时，椎间裂隙会发生并逐渐充气，这可能会导致下腰痛，加剧腰椎间盘退变。如上所述，我们假设终板退化可能是真空现象的起因。(C)2010爱思唯尔有限公司。保留所有权利。
The intravertebral vacuum phenomenon (VP) is usually associated with degenerative disc disease, which could be related to the low back pain. Various theories related to the pathogenesis of VP have been proposed, but these theories have not been critically examined and remain hypothetical. In this article, we review the possible role of endplate degeneration in the pathogenesis of VP, and discuss several pathways possibly linked to them. Due to the endplate calcification and activated cytokines, the transport pathway of the nutrition for the intervertebral disc was blocked, resulting in the metabolic unbalance and decrease of the synthesis of matrix structural proteins. It could promote the matrix decomposition, causing the decrease of the quantity of matrix and the changes of stress distribution in intervertebral disc. As a result, the structure of intervertebral discs became increasingly unstable. While compression happened, the intravertebral cleft could occur and be gradually filled with gas, which may cause low back pain and aggravate the intervertebral discs degeneration. As outlined above, we hypothesize that endplate degeneration might be the origination of the vacuum phenomenon. (C) 2010 Elsevier Ltd. All rights reserved.