BIOENGINEERING IN DEVELOPMENT OF THE HYBRID ARTIFICIAL PANCREAS
BIOENGINEERING IN DEVELOPMENT OF THE HYBRID ARTIFICIAL PANCREAS
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DOI：
10.1115/1.2891229
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发表时间：
1991-05-01
影响因子：
1.7
通讯作者：
AVGOUSTINIATOS, ES
中科院分区：
文献类型：
--
作者：
COLTON, CK;AVGOUSTINIATOS, ES
用于治疗糖尿病的混合人工胰腺由分泌胰岛素的胰腺组织组成，该组织周围有一层膜，可保护组织在植入后免受免疫系统的排斥。在本文中，我们回顾了正在研究的糖尿病的替代治疗方法，然后讨论了对人类有用的混合设备必须满足的技术要求。从这些要求的角度回顾了先前关于血管内和血管外免疫隔离装置的工作，并讨论了三个尚未解决的关键问题：生物相容性、供氧限制和预防免疫排斥。
The hybrid artificial pancreas for treatment of diabetes consists of insulin-secreting pancreatic tissue which is surrounded by a membrane that protects the tissue from rejection by the immune system following implantation. In this paper, we review the alternative therapeutic approaches for diabetes under study and then discuss the technical requirements that must be met by a hybrid device useful to humans. Previous work on intravascular and extravascular immunoisolation devices is reviewed from the standpoint of these requirements, and three critical unresolved issues are discussed: biocompatibility, oxygen supply limitations, and prevention of immune rejection.