Effects of pre-junctional alpha-receptor blockade on vascular neuro-effector characteristics in rats on high sodium intake.
Effects of pre-junctional alpha-receptor blockade on vascular neuro-effector characteristics in rats on high sodium intake.
复制标题
结前α受体阻断对高钠摄入大鼠血管神经效应器特征的影响。
DOI：
10.1111/j.1748-1716.1989.tb08774.x
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
B. Folkow
中科院分区：
文献类型：
--
作者：
N. Sjöblom;H. Nilsson;H. Gustafsson;D. Ely;B. Folkow
Various in-vitro studies have indicated a direct attenuating effect of sodium on the affinity of adrenergic alpha 2-receptors. It has been suggested that ingested sodium in this way might increase blood pressure by reducing the activity of central alpha 2-receptors and thereby increasing sympathetic discharge. However, such an effect of sodium would also impair the function of peripheral alpha 2-receptors. In the present study we have therefore investigated the effect of high sodium intake on the alpha 2-receptor-mediated inhibition of the vascular neurogenic response. Male Wistar rats were given 2% NaCl in their drinking water from 4 to 9 weeks of age. Another group receiving plain tap water served as controls. Segments of small branches from the mesenteric artery were mounted in a myograph. Responses to transmural nerve stimulation were determined before and after alpha 2-receptor blockade with either yohimbine or idazoxan. The response to a continuous nerve stimulation that elicited 30% of maximal contraction was increased 2-3 times after addition of either idazoxan (0.1 microM) or yohimbine (0.3 microM), with no significant difference between sodium-treated and control rats; if anything the enhancement was slightly greater in the sodium-treated group. Also, responses to intermittent burst stimulation were increased from 30 to about 80% of maximal response in both rat groups. The results thus indicate that high sodium intake does not affect the inhibitory influence of pre-junctional alpha 2-receptors on the vascular neurogenic response.
自发性高血压大鼠中枢α2-肾上腺素能受体的钠反应性。
DOI：
10.1161/01.hyp.11.4.326
发表时间：
1988
期刊：
Hypertension (Dallas, Tex. : 1979)
影响因子：
--
作者：
Koepke,JP;Jones,S;DiBona,GF
通讯作者：
DiBona,GF
影响因子：
8.3
作者：
H. Gavras
通讯作者：
H. Gavras
大鼠盐敏感性的神经基础：下丘脑功能改变。
DOI：
10.1097/00000441-198804000-00024
发表时间：
1988
期刊：
The American journal of the medical sciences
影响因子：
--
作者：
Oparil,S;Chen,YF;Meng,QC;Yang,RH;Jin,HK;Wyss,JM
通讯作者：
Wyss,JM