Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a.
Shaping of inner ear sensory organs through antagonistic interactions between Notch signalling and Lmx1a.
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DOI：
10.7554/elife.33323
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发表时间：
2017-12-04
期刊：
影响因子：
7.7
通讯作者：
Daudet N
中科院分区：
文献类型：
--
作者：
Mann ZF;Gálvez H;Pedreno D;Chen Z;Chrysostomou E;Żak M;Kang M;Canden E;Daudet N
内耳不同感觉器官的形成机制和将它们分开的非感觉域尚不清楚。在这里，我们发现在胚胎鸡和小鼠耳囊肿中，几个感觉斑块从一个共同的前感觉区域逐渐分离出来。这个过程是由相互拮抗的信号调控的：Notch信号和Lmx1a。缺口介导的侧诱导促进前感觉命运。然而，一些早期的有notch活性的细胞通常会偏离这种命运，增加的侧向诱导会在小鸡中产生畸形或融合的感觉器官。相反，Lmx1a（或小鸡中的cLmx1b）通过拮抗侧诱导和促进对非感觉命运的承诺而允许感觉器官分离。我们的研究结果强调了感觉斑块形成的动态性和感觉能力祖细胞的不稳定性，这可能促进了新的内耳器官的出现及其在进化过程中的功能多样化。
The mechanisms of formation of the distinct sensory organs of the inner ear and the non-sensory domains that separate them are still unclear. Here, we show that several sensory patches arise by progressive segregation from a common prosensory domain in the embryonic chicken and mouse otocyst. This process is regulated by mutually antagonistic signals: Notch signalling and Lmx1a. Notch-mediated lateral induction promotes prosensory fate. Some of the early Notch-active cells, however, are normally diverted from this fate and increasing lateral induction produces misshapen or fused sensory organs in the chick. Conversely Lmx1a (or cLmx1b in the chick) allows sensory organ segregation by antagonizing lateral induction and promoting commitment to the non-sensory fate. Our findings highlight the dynamic nature of sensory patch formation and the labile character of the sensory-competent progenitors, which could have facilitated the emergence of new inner ear organs and their functional diversification in the course of evolution.