The Pattern of Glomerular Map Formation Defines Responsiveness to Aversive Odorants in Mice
The Pattern of Glomerular Map Formation Defines Responsiveness to Aversive Odorants in Mice
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DOI：
10.1523/jneurosci.2460-10.2011
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发表时间：
2011-05-25
影响因子：
5.3
通讯作者：
Cloutier, Jean-Francois
中科院分区：
文献类型：
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作者：
Cho, Jin Hyung;Prince, Janet E. A.;Cloutier, Jean-Francois
在许多物种中，气味的检测和识别对于调节生存所必需的行为至关重要，例如觅食和躲避捕食者。嗅觉感觉神经元（OSNs）和嗅球（OB）中的二级神经元之间复杂的刻板联系的形成被认为是准确的气味信息处理的重要因素。在小鼠中，神经支配OB背侧区域的OSN的消融导致响应于厌恶和捕食者气味剂的回避行为的丧失（Kobayakawa等人，2007年）。这仍然有待确定是否准确形成一个肾小球地图在该地区的OB是需要这些先天性反应。在这里，我们已经产生了在OSN中缺乏轴突导向受体Robo-2表达的小鼠，并发现Robo-2表达的消融导致OB背侧区域内OSN轴突子集的错误定位。此外，这些小鼠表现出对捕食者气味三甲基噻唑啉的回避行为减少。我们的研究结果表明，在OB的肾小球神经支配的模式是至关重要的先天性行为反应的小鼠。
In many species, the detection and recognition of odors is critical to regulate behaviors that are essential for survival, such as foraging for food and avoidance of predators. The formation of complex stereotypic connections between olfactory sensory neurons (OSNs) and second-order neurons in the olfactory bulb (OB) is believed to be important for accurate odorant information processing. In mice, ablation of OSNs that innervate the dorsal region of the OB leads to a loss of avoidance behavior in response to aversive and predator odorants (Kobayakawa et al., 2007). It remains to be determined whether the accurate formation of a glomerular map in this region of the OB is required for these innate responses. Here, we have generated mice that lack expression of the axon guidance receptor Robo-2 in OSNs and found that ablation of Robo-2 expression leads to mistargeting of subsets of OSN axons within the dorsal region of the OB. Furthermore, these mice show decreased avoidance behavior toward the predator odorant trimethyl-thiazoline. Our results indicate that the pattern of glomerular innervation in the OB is critical for innate behavioral responses in mice.