Biological scaffolds for heart valve tissue engineering.
Biological scaffolds for heart valve tissue engineering.
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DOI：
10.1007/978-1-59745-443-8_17
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
A. Lichtenberg;S. Cebotari;I. Tudorache;A. Hilfiker;A. Haverich
中科院分区：
文献类型：
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作者：
A. Lichtenberg;S. Cebotari;I. Tudorache;A. Hilfiker;A. Haverich
组织工程可能为克服生物和机械心脏瓣膜替代品的局限性提供有希望的解决方案。心脏瓣膜组织工程的概念基于去细胞化的生物基质，因为去除细胞成分可能会减少免疫反应，而免疫反应被认为是加速瓣膜移植物退化和随后自体细胞再生的原因，从而导致组织完整性和持续重塑。在这里，我们报告了一种用洗涤剂从羊心脏瓣膜组织（包括尖、壁和心肌袖带）中有效去除细胞的方法，用于制造生物瓣膜支架。
Tissue engineering might bear promising solutions for overcoming the limitations of biological and mechanical heart valve substitutes. The concept of heart valve tissue engineering bases on decellularized biological matrices, as removal of cellular components might reduce immunological reactions, which are thought to be responsible for accelerated valvular graft deterioration and their subsequent repopulation with autologous cells, which leads to tissue integrity and continuous remodeling. Here, we report a method for efficient removal of cells from ovine heart valve tissue (including cusp, wall, and myocardial cuff) by detergents for the generation of biological valvular scaffolds.