Induction of xanthine oxidase and depression of cytochrome P-450 by interferon inducers: genetic difference in the responses of mice.
Induction of xanthine oxidase and depression of cytochrome P-450 by interferon inducers: genetic difference in the responses of mice.
复制标题
干扰素诱导剂诱导黄嘌呤氧化酶并抑制细胞色素 P-450：小鼠反应的遗传差异。
DOI：
10.1016/0006-291x(85)91777-2
复制
发表时间：
1985
影响因子：
3.1
通讯作者：
Mannering,GJ
中科院分区：
文献类型：
--
作者：
Deloria,L;Abbott,V;Gooderham,N;Mannering,GJ
干扰素和干扰素诱导剂抑制肝细胞色素P-450系统。它们还能诱导肝黄嘌呤氧化酶活性。黄嘌呤氧化酶产生的自由基可能导致P-450的丢失。在C57B1/6J和C3H/HeJ小鼠中，poly IC （poly riboinosinic acid·polyribocytidylic acid）均能诱导高滴度的血清干扰素；新城疫病毒（NDV）在C57B1/6J小鼠体内可诱导高滴度的干扰素，而在C3H/HeJ小鼠体内则无。NDV对C3H/HeJ小鼠黄嘌呤氧化酶活性的诱导低于C57B1/6J小鼠的一半，从而表明黄嘌呤氧化酶的诱导、P-450的抑制与小鼠对干扰素诱导剂的反应性差异之间存在遗传决定的关系。
Interferon and interferon inducing agents depress hepatic cytochrome P-450 systems. They also induce hepatic xanthine oxidase activity. It has been suggested that free radicals produced by xanthine oxidase may cause the loss of P-450. High titers of serum interferon are induced by poly IC (poly riboinosinic acid · polyribocytidylic acid) in both C57B1/6J and C3H/HeJ mice; Newcastle disease virus (NDV) induces a high titer of interferon in C57B1/6J mice but not in C3H/HeJ mice. The induction of xanthine oxidase activity by NDV in C3H/HeJ mice was less than half that seen in C57B1/6J mice, thus demonstrating a relationship between the induction of xanthine oxidase, the depression of P-450 and a genetically determined difference in responsiveness of mice to interferon inducers.