Grid cells require excitatory drive from the hippocampus
Grid cells require excitatory drive from the hippocampus
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DOI：
10.1038/nn.3311
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发表时间：
2013-03-01
影响因子：
25
通讯作者：
Moser, May-Britt
中科院分区：
文献类型：
--
作者：
Bonnevie, Tora;Dunn, Benjamin;Moser, May-Britt
为了确定海马回投射如何影响网格细胞的空间周期性放电，我们记录了海马暂时失活后大鼠内侧内嗅皮层（MEC）的神经活动。我们报告两个主要的变化，内嗅网格细胞。首先，海马失活逐渐和选择性地熄灭了网格模式。第二，失去网格场的网格细胞获得了对大鼠头部方向的实质性调整。放电特性的这种转变取决于网格细胞的平均放电率的下降，并且可以通过在吸引子网络模型中去除外部兴奋性驱动来复制，在吸引子网络模型中，网格结构通过具有抑制性连接的网络中的活动的速度依赖性翻译而出现。这些结果表明，来自海马和可能其他区域的兴奋性驱动是MEC中网格模式形成和移位的先决条件之一。
To determine how hippocampal backprojections influence spatially periodic firing in grid cells, we recorded neural activity in the medial entorhinal cortex (MEC) of rats after temporary inactivation of the hippocampus. We report two major changes in entorhinal grid cells. First, hippocampal inactivation gradually and selectively extinguished the grid pattern. Second, the same grid cells that lost their grid fields acquired substantial tuning to the direction of the rat's head. This transition in firing properties was contingent on a drop in the average firing rate of the grid cells and could be replicated by the removal of an external excitatory drive in an attractor network model in which grid structure emerges by velocity-dependent translation of activity across a network with inhibitory connections. These results point to excitatory drive from the hippocampus, and possibly other regions, as one prerequisite for the formation and translocation of grid patterns in the MEC.