Polysensory interactions along lateral temporal regions evoked by audiovisual speech.
Polysensory interactions along lateral temporal regions evoked by audiovisual speech.
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DOI：
10.1093/cercor/13.10.1034
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发表时间：
2003-10
期刊：
影响因子：
3.7
通讯作者：
T. Wright;K. Pelphrey;T. Allison;M. McKeown;G. McCarthy
中科院分区：
文献类型：
--
作者：
T. Wright;K. Pelphrey;T. Allison;M. McKeown;G. McCarthy
许多具有社会意义的生物刺激是多模式的，并且多模式刺激的信息处理比单模式刺激的信息处理更强。人类的颞上沟(STS)区域被认为与处理社会相关的刺激有关--特别是那些来自生物运动的刺激，如嘴巴运动。对猴子的单一单位研究表明，STS的区域是多感官的--对视觉、听觉和躯体感觉刺激做出反应，人类神经成像研究表明，读唇语激活了外侧颞叶的听觉区域。我们评估了同时发出的语音和嘴巴的运动是否比单独的语音或嘴巴运动更有效地激活了STS。在一项与事件相关的功能磁共振研究中，受试者观察了一个动画角色，这个角色只产生视听语音和语音的音频和视觉成分。STS区的强烈激活在所有三种情况下都被唤起，其中视听语言的激活程度最高。STS区域内激活的体素的子集表现出过可加性(视听+视听)和低可加性(视听+视听)。这些结果证实了STS区域的多感觉特性，并首次证明了多通道相互作用可能既增强又抑制激活。
Many socially significant biological stimuli are polymodal, and information processing is enhanced for polymodal over unimodal stimuli. The human superior temporal sulcus (STS) region has been implicated in processing socially relevant stimuli--particularly those derived from biological motion such as mouth movements. Single unit studies in monkeys have demonstrated that regions of STS are polysensory--responding to visual, auditory and somato-sensory stimuli, and human neuroimaging studies have shown that lip-reading activates auditory regions of the lateral temporal lobe. We evaluated whether concurrent speech sounds and mouth movements were more potent activators of STS than either speech sounds or mouth movements alone. In an event-related fMRI study, subjects observed an animated character that produced audiovisual speech and the audio and visual components of speech alone. Strong activation of the STS region was evoked in all three conditions, with greatest levels of activity elicited by audiovisual speech. Subsets of activated voxels within the STS region demonstrated overadditivity (audiovisual > audio + visual) and underadditivity (audiovisual < audio + visual). These results confirm the polysensory nature of STS region and demonstrate for the first time that polymodal interactions may both potentiate and inhibit activation.