FGF signaling in mandibular skeletogenesis.
FGF signaling in mandibular skeletogenesis.
复制标题
下颌骨骼发生中的 FGF 信号传导。
DOI：
10.1111/j.1601-6343.2007.00385.x
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发表时间：
2007
影响因子：
3.1
通讯作者：
Havens,Bruce
中科院分区：
文献类型：
--
作者：
Mina,Mina;Havens,Bruce
结构摘要作者-Mina M，Havens B目的-检查FGF/FGFR信号传导在下颌骨骨发生过程中的功能。设计-我们通过在鸡下颌骨突中过表达编码截短形式FGFR 3的可复制RCAS病毒来检查在下颌骨发生过程中FGF信号传导抑制的作用。 在发育的早期阶段注射导致Meckel软骨的截断，严重减少了下颌突的生长，并且缺少了五块下颌骨。在后期注射不会影响下颌突和Meckel软骨的生长，但会以特定区域的方式导致下颌骨成骨异常。在更尾部区域的骨经常被截断，而在更喙部区域，如齿骨和压骨骨的骨经常absent.Conclusion-在一起，这些实验揭示了FGF/FGFR信号在梅克尔软骨的伸长，成骨凝聚和附着生长的下颌骨的发展中的重要作用。
Structured AbstractAuthors –Mina M, Havens BObjective –To examine the functions of FGF/FGFR signaling during mandibular skeletogenesisin ovo.Design –We examined the effects of inhibition of FGF signaling during mandibular skeletogenesis by overexpressing replication‐competent RCAS virus encoding a truncated form of FGFR3 in the chicken mandibular process between stages 17 and 26.Results –Injection of RCAS‐dnFGFR3 into the developing mandible resulted in abnormalities in a stage‐ and region‐dependent manner. Injection at early stages of development resulted in the truncation of Meckel's cartilage, severely reduced outgrowth of the mandibular process and absence of five of the mandibular bones. Injection at later stages did not affect the outgrowth of the mandibular process and Meckel's cartilage but resulted in abnormalities in mandibular osteogenesis in a region‐specific manner. The bones in the more caudal region were frequently truncated whereas bones in the more rostral regions such as dentary and splenial bones were frequently absent.Conclusion –Together these experiments have revealed essential roles for FGF/FGFR signaling in the elongation of Meckel's cartilage, development of osteogenic condensations and appositional growth of mandibular bones.