IMMUNOLOGICAL STUDIES ON OPPORTUNISTIC INFECTION AND THE DEVELOPMENT OF ADULT T-CELL LEUKEMIA
IMMUNOLOGICAL STUDIES ON OPPORTUNISTIC INFECTION AND THE DEVELOPMENT OF ADULT T-CELL LEUKEMIA
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DOI：
10.2169/internalmedicine.31.1132
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发表时间：
1992-09-01
影响因子：
1.2
通讯作者：
NASU, M
中科院分区：
文献类型：
--
作者：
TASHIRO, T;YAMASAKI, T;NASU, M
本文报道3例成人t细胞白血病（ATL）前机会性感染患者：66岁女性伴隐球菌病和卡氏肺囊虫肺炎，46岁男性伴卡氏肺囊虫肺炎，55岁女性伴隐球菌病。虽然在第一次检查时，前两例为阴燃型ATL，第三例为HTLV-I携带者，但在机会性感染发病14-16个月后，这三例均出现明显的ATL。我们认为HTLV-I携带者和阴燃ATL患者已经存在免疫抑制，机会性感染可预测ATL的发展。
Three patients with opportunistic infection preceding adult T-cell leukemia (ATL) are presented: a 66-year-old woman with cryptococcosis and Pneumocystis carinii pneumonia, a 46-year-old man with Pneumocystis carinii pneumonia, and a 55-year-old woman with cryptococcosis. Although, at the first examination, the first two had smoldering type ATL and the third case was an HTLV-I carrier, all three developed overt ATL 14-16 months after the onset of opportunistic infection. It is considered that there is immune suppression already present in HTLV-I carriers and in patients with smoldering ATL, and opportunistic infection is predictive of the development of ATL.