Metabolic changes in human muscle denervation: Topical 31P NMR spectroscopy studies
Metabolic changes in human muscle denervation: Topical 31P NMR spectroscopy studies
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人体肌肉去神经的代谢变化：局部 31P NMR 波谱研究
DOI：
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发表时间：
1988
影响因子：
3.3
通讯作者：
C. Bolton
中科院分区：
文献类型：
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作者：
D. Zochodne;R. Thompson;A. Driedger;M. J. Strong;D. Gravelle;C. Bolton
应用~（31）P核磁共振波谱技术研究了人前臂屈肌部分或完全失神经支配后的代谢变化。在静息肌中，肌电图证实的前臂屈肌失神经患者的PCr/Pi比值低于健康对照组[4.76 ± 2.50（SD）vs 6.50 ± 1.55（SD）; P < 0.01]，细胞内pH值高于健康对照组[7.09 ± 0.06 vs 7.05 ± 0.04（SD; P < 0.01]。这些变化是更明显的患病手臂相比，对侧健康的手臂在患者严格的单侧去神经。5例严重失神经支配患者的PCr/Pi比值最低（1.94 ± 0.70），pH值最高（7.15 ± 0.04）。4例前臂骨折导致的神经支配完整和废用性萎缩的患者在移除前臂石膏后没有立即表现出这些变化。研究结果表明，去神经支配导致PCr/P的减少，肌肉内和细胞内pH值的上升，这些变化与去神经支配的程度相关，并随着恢复而改善。31 P MRS可用于失神经萎缩的随访。出版社：Academic Press，Inc.
Metabolic changes in human forearm flexor muscle following partial or complete denervation were studied using 31P nuclear magnetic resonance spectroscopy. In resting muscle, patients with electromyographically verified forearm flexor denervation had a lower ratio of PCr/Pi than healthy controls [4.76 ± 2.50 (SD) versus 6.50 ± 1.55 (SD); P < 0.01] and a higher intracellular pH [7.09 ± 0.06 versus 7.05 ± 0.04 (SD); P < 0.01]. These changes were more apparent when the diseased arm was compared to the contralateral healthy arm in patients with strictly unilateral denervation. Five patients with severe denervation had the lowest PCr/Pi ratio (1.94 ± 0.70) and the highest pH (7.15 ± 0.04). Four patients with intact innervation and disuse atrophy as a result of a forearm fracture did not exhibit these changes immediately following removal of the forearm cast. The findings show that denervation leads to a reduction in PCr/P, within muscle and a rise in intracellular pH, and that these changes correlate with the degree of denervation and improve with recovery. 31P MRS may be useful to follow the course of denervation atrophy. © 1988 Academic Press, Inc.
31P核磁共振波谱：缺血肢体的无创生化分析。
影响因子：
4.3
作者：
Zatina,MA;Berkowitz,HD;Gross,GM;Maris,JM;Chance,B
通讯作者：
Chance,B