Anthropometric and metabolic factors and risk of benign prostatic hyperplasia: A prospective cohort study of Air Force veterans
Anthropometric and metabolic factors and risk of benign prostatic hyperplasia: A prospective cohort study of Air Force veterans
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DOI：
10.1016/j.urology.2006.09.034
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发表时间：
2006-12-01
期刊：
影响因子：
2.1
通讯作者：
Roehrborn, Claus G.
中科院分区：
文献类型：
--
作者：
Gupta, Amit;Gupta, Sachin;Roehrborn, Claus G.
目标。人体测量和代谢因素与良性前列腺增生（BPH）之间的关系知之甚少。在这项针对越战退伍军人的前瞻性研究中，我们调查了 BPH 与人体测量和代谢参数的关联。方法。本研究纳入了空军健康研究对比组的 1206 名参与者，中位随访时间为 15.6 年。因职业接触除草剂的“牧场工人”组被排除在外，以消除接触除草剂造成的任何混淆。 BPH 是通过使用《国际疾病和相关问题分类》第九版修订版的病历审查来确定的。我们使用Cox比例风险回归模型进行统计分析。结果。 BPH 诊断的中位年龄为 58.6 岁。在多变量分析中，年龄增加（相对风险[RR] 1.14，95%置信区间[CI] 1.12至1.17）、身高（RR 1.02，95% CI 1.004至1.03）和空腹血糖（RR 1.004，95% CI 1.001至1.007）与风险增加相关。年龄的影响随着随访时间的长短而变化。较高的收缩压（RR 0.992，95% CI 0.986 至 0.997）与 BPH 风险降低相关。年龄、身高和收缩压存在剂量反应效应。没有发现对体重、体重指数、体重或体重指数变化、血脂、甲状腺激素状态或代谢综合征有影响。结论。前列腺肥大的风险随着年龄、身高和空腹血糖水平的增加而增加。收缩压越高，风险就越低。 BPH 与代谢综合征、体重、体重指数、血脂水平或甲状腺激素状态之间没有关系。
Objectives. The relationship between anthropometric and metabolic factors and benign prostatic hyperplasia (BPH) is poorly understood. We investigated the associations of BPH with anthropometric and metabolic parameters in this prospective study of Vietnam War veterans.Methods. A total of 1206 participants in the comparison arm of the Air Force Health Study with a median follow-up of 15.6 years were included in this study. The "Ranch Hand" group, occupationally exposed to herbicides, was excluded to eliminate any confounding from exposure to herbicides. BPH was determined by medical record review using the International Classification of Diseases and Related Problems, Ninth Revision. We used Cox proportional hazards regression models for the statistical analysis.Results. The median age for BPH diagnosis was 58.6 years. On multivariate analyses, increasing age (relative risk [RR] 1.14, 95% confidence interval [CI] 1.12 to 1.17), height (RR 1.02, 95% CI 1.004 to 1.03), and fasting blood glucose (RR 1.004, 95% CI 1.001 to 1.007) were associated with increased risk. The effect of age varied with the duration of follow-up. A greater systolic blood pressure (RR 0.992, 95% CI 0.986 to 0.997) was associated with decreased risk of BPH. A dose-response effect was seen for age, height, and systolic blood pressure. No effect was seen for weight, body mass index, change in weight or body mass index, lipids, thyroid hormone status, or the metabolic syndrome.Conclusions. The risk of BPH increased with increasing age, height, and fasting blood glucose levels. The risk was decreased with a greater systolic blood pressure. No relationship was seen between BPH and metabolic syndrome, weight, body mass index, lipid level, or thyroid hormone status.