Electrical stimulation of the ventral tegmental area and catecholamine metabolism in discrete regions of the rat brain
Electrical stimulation of the ventral tegmental area and catecholamine metabolism in discrete regions of the rat brain
复制标题
大鼠大脑离散区域腹侧被盖区的电刺激和儿茶酚胺代谢
DOI：
10.1016/0006-8993(83)90505-x
复制
发表时间：
1983
期刊：
影响因子：
2.9
通讯作者：
D. Versteeg
中科院分区：
文献类型：
--
作者：
D. Heuven;L. Wolfswinkel;J. M. Ree;D. Versteeg
数据显示不同模式的多巴胺和去甲肾上腺素利用率在终端地区的A9和A10多巴胺能系统和终端地区的背侧去甲肾上腺素束后，电刺激腹侧被盖区和邻近地区。在该网站的电极增强营业额的去甲肾上腺素被found.These结果进行了讨论有关的位置的电极网站和位置的多巴胺能细胞体A9和A10和儿茶酚胺能纤维通过MFB支配前脑和边缘结构。可以得出结论，激活部分A10多巴胺能系统和A6去甲肾上腺素能系统与颅内自我刺激。
Data are presented which show a different pattern of dopamine and noradrenaline utilization in terminal regions of the A9 and A10 dopaminergic systems and in terminal regions of the dorsal noradrenergic bundle after electrical stimulation of the ventral tegmental area and an adjacent area. At the sites of the electrodes an enhanced turnover of noradrenaline was found. These results are discussed relating the location of the electrode sites and the location of the dopaminergic cell bodies A9 and A10 and catecholaminergic fibers passing through the MFB innervating forebrain and limbic structures. It is concluded that activation of parts of the A10 dopaminergic system and the A6 noradrenergic system is correlated with intracranial selfstimulation.