Noradrenaline mediates slow excitatory synaptic potentials in rat dorsal raphe neurons in vitro
Noradrenaline mediates slow excitatory synaptic potentials in rat dorsal raphe neurons in vitro
复制标题
去甲肾上腺素在体外介导大鼠中缝背神经元的慢兴奋性突触电位
DOI：
10.1016/0304-3940(85)90481-1
复制
发表时间：
1985
影响因子：
2.5
通讯作者：
S. Nishi
中科院分区：
文献类型：
--
作者：
M. Yoshimura;H. Higashi;S. Nishi
重复局灶性刺激大鼠脑片中缝背核（DR）区域内的表面，在大多数DR神经元中引起慢兴奋性突触电位（slow EPSP），随后是慢抑制性突触电位（slow IPSP）。缓慢的EPSP与膜阻力的增加或减少有关。去甲肾上腺素（NA）的应用引起了大多数DR神经元的膜去极化。NA诱导的去极化也伴随着膜电阻的增加或减少。酚妥拉明和哌唑嗪均能抑制慢EPSP和NA诱发的去极化，育亨宾和普萘洛尔则无此作用。结果提示，大鼠DR神经元的慢EPSP是由NA与α1肾上腺素受体相互作用而介导的。
Repetitive focal stimulation to the slice surface within the region of the dorsal raphe (DR) nucleus of rat brain elicited a slow excitatory synaptic potential (slow EPSP), which followed a slow inhibitory synaptic potential (slow IPSP) in a majority of the DR neurons. The slow EPSPs were associated with either an increase or a decrease in membrane resistance. Noradrenaline (NA) application caused a membrane depolarization in most of the DR neurons. The NA-induced depolarization was also accompanied by either an increase or a decrease in membrane resistance. Both the slow EPSP and NA-induced depolarization were inhibited by phentolamine and prazosin but not by yohimbine and propranolol. The result suggests that slow EPSPs in rat DR neurons are mediated by NA interacting with anα1-adrenoceptor.