Highly regioselective CH bond functionalization of imidazo[1,2-a]pyridines with aryl halides catalyzed by Ru-arene complex
Highly regioselective CH bond functionalization of imidazo[1,2-a]pyridines with aryl halides catalyzed by Ru-arene complex
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DOI：
10.1016/j.catcom.2012.04.032
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发表时间：
2012-09
影响因子：
3.7
通讯作者：
Hai Yang;Liping Yang;Yuan Li;Z. Fan;Huajie Liu;B. Yi
中科院分区：
文献类型：
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作者：
Hai Yang;Liping Yang;Yuan Li;Z. Fan;Huajie Liu;B. Yi
报道了钌催化咪唑[1,2-a]吡啶与芳基卤化物的有效偶联反应，通过CH键裂解合成了多取代咪唑[1,2-a]吡啶。本研究提出了一种合成多取代咪唑[1,2-a]吡啶的简便方法，这是天然产物和药物中常见的结构基序。[RuCl2（对伞花烃）]2和cs2co3存在于DMF中，温度120℃，反应15h后可得到产量可观的理想产物。
An effective Ru-catalyzed coupling reaction of imidazo[1,2-a]pyridines and aryl halides is reported for the synthesis of polysubstituted imidazo[1,2-a]pyridines through CH bond cleavages. The current study presents a convenient strategy to synthesize polysubstituted imidazo[1,2-a]pyridine, a common structural motif in natural products and pharmaceuticals. Desired products in considerable yields can be obtained in the presences of [RuCl2(p-cymene)]2and Cs2CO3in DMF at 120°C after 15h.