The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge.
The MRI colonic function test: Reproducibility of the Macrogol stimulus challenge.
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MRI 结肠功能测试：聚乙二醇刺激挑战的重现性。
DOI：
10.1111/nmo.13942
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发表时间：
2020
影响因子：
3.5
通讯作者：
Wilkinson-Smith V
中科院分区：
文献类型：
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作者：
Wilkinson-Smith V
背景磁共振成像（MRI）显示结肠对聚乙二醇激发饮料的反应可用于评估严重便秘的机制。我们测量了结肠功能 MRI 测量的受试者内可重复性，以帮助其作为可能的临床测试实施。方法健康参与者两次参加 MRI（相同的方案，至少相隔 1 周）。他们进行了空腹扫描，然后饮用了聚乙二醇饮料。在 60 分钟和 120 分钟时对受试者进行扫描，达到的最大值用于比较。测量结肠体积、含水量、结肠内容物的混合和结肠壁的运动。计算变异系数和组内相关系数 (ICC)。结果 12 名参与者完成了研究：9 名女性，平均年龄 26 岁 (SD 5)，体重指数 24.8 kg/m2 (SD 3.2)。在用聚乙二醇激发后，所有测量值均持续高于基线。体积、含水量和内容物混合具有良好的受试者内重现性（ICC体积= 0.84，含水量= 0.93，混合= 0.79，P<.001）。随着壁运动，对挑战的反应通常很大，但每次就诊之间的变化更大，导致整体 ICC 较低（升结肠 = 0.65，降结肠 = 0.76，P < .001）。 结论 MRI 评估的结肠对聚乙二醇刺激的反应是异质的，但与基线相比较大，具有中等到良好的重现性，使得该测试适合研究便秘等胃肠道疾病的潜在病理。需要更多数据来更好地定义正常范围，以便与可能同时具有运动不足和过度运动反应的患者组进行比较。
BackgroundMagnetic resonance imaging (MRI) of the colonic response to a macrogol challenge drink can be used to assess the mechanisms underlying severe constipation. We measured the intrasubject reproducibility of MRI measures of colonic function to aid their implementation as a possible clinical test.MethodsHealthy participants attended for MRI on two occasions (identical protocols, minimum 1 week apart). They underwent a fasted scan and then consumed the macrogol drink. Subjects were scanned at 60 and 120 minutes, with maximum value reached used for comparison. The colonic volume, water content, mixing of colonic content and the movement of the colon walls were measured. Coefficients of variation and intraclass correlation coefficients (ICC) were calculated.ResultsTwelve participants completed the study: nine female, mean age 26 years (SD 5) and body mass index 24.8 kg/m2(SD 3.2). All measures consistently increased above baseline following provocation with macrogol. The volume, water content and content mixing had good intrasubject reproducibility (ICC volume = 0.84, water content = 0.93, mixing = 0.79,P< .001). With the wall movement, the response to the challenge was generally large, but more variable between visits resulting in a lower ICC overall (ascending colon = 0.65, descending colon = 0.76,P< .001).ConclusionsThe colonic response to the macrogol stimulus as assessed by MRI is heterogeneous but large compared to baseline, with moderate to good reproducibility, making the test suitable to study potential pathologies underlying GI disorders such as constipation. More data are needed to better define the normal range for comparison with patient groups who may have both hypo‐ and hypermotile responses.