Excess lung cancer among workers exposed to lead
Excess lung cancer among workers exposed to lead
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DOI：
10.5271/sjweh.62
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发表时间：
1995-12-01
影响因子：
6.3
通讯作者：
Hemminki, K
中科院分区：
文献类型：
--
作者：
Anttila, A;Heikkila, P;Hemminki, K
目的实验动物研究表明，无机铅是一种致癌物质。本研究的目的是探讨是否职业暴露于铅增加cancer.Methods的风险的研究人群包括20 700名工人谁已被生物监测他们的血铅（B-Pb）浓度在1973-1983年。对受监测工人的死亡率和癌症发病率进行了跟踪，并与芬兰一般人口的死亡率和癌症发病率进行了比较。根据个体B-Pb水平形成的亚队列之间也进行了癌症发病率的内部比较。还收集了关于终生职业史和潜在混杂因素的基于病历的信息，结果队列内的内部比较显示，肺癌的总发病率增加了1.4倍，肺癌的总发病率增加了1.8倍，在血铅水平大于或等于1.0 μ mol的人群中，肺癌的发病率会增加一倍。1（-1）。在病例对照研究中，发现同时暴露于铅和发动机废气的肺癌几率比增加。即使血铅水平略有升高，肺鳞状细胞癌的优势比也会增加。偏倚或混杂不能解释的risks.Conclusions结果表明，暴露于铅增加肺癌的风险。接触发动机废气和铅可能与风险有关。
Objective Studies on experimental animals suggest that inorganic lead is a carcinogen. The purpose of the study was to examine whether occupational exposure to lead increases the risk of cancer.Methods The study population comprised 20 700 workers who had been biologically monitored for their blood lead (B-Pb) concentrations during 1973-1983. The mortality and cancer incidence rates were followed among the monitored workers and compared with those of the Finnish general population. An internal comparison of the cancer incidence rates was also done between subcohorts formed according to individual B-Pb levels. Questionnaire-based information was also collected on lifetime occupational history and potential confounders, and exposure history was assessed on an individual basis with a nested case-referent design for lung cancer.Results The internal comparison within the cohort showed a 1.4-fold increase in the overall cancer incidence and a 1.8-fold increase in the incidence of lung cancer among those who had ever had a blood lead level of greater than or equal to 1.0 mu mol . 1(-1). In the case-referent study, an increased odds ratio for lung cancer was found for concomitant exposure to lead and engine exhaust. The odds ratio for squamous-cell carcinoma of the lung was increased even when the blood lead level had been slightly elevated. Bias or confounding did not explain the risks.Conclusions The results suggest that exposure to lead increases the risk of lung cancer. Go-exposure to engine exhaust and lead may be associated with the risk.