Comparison of perinatal outcomes between long-term and short-term use of tocolytic agent: a historical cohort study in a single perinatal hospital
Comparison of perinatal outcomes between long-term and short-term use of tocolytic agent: a historical cohort study in a single perinatal hospital
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DOI：
10.1111/jog.13104
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发表时间：
2016-12-01
影响因子：
1.6
通讯作者：
Sekizawa, Akihiko
中科院分区：
文献类型：
--
作者：
Nakamura, Masamitsu;Hasegawa, Junichi;Sekizawa, Akihiko
目的：本研究的目的是评估长期使用保胎药物，以防止早产和改善围产儿outcome.Methods的效果：在一个单一的围产期中心进行历史队列研究。结果：先兆早产保胎药使用方案变更前共分娩1548例，变更后共分娩1444例，两组孕妇的临床特征、早产发生率及保胎药使用剂量进行比较。修订前后产妇特征除年龄外无显著性差异。使用的盐酸利托君安瓿总数从4654瓶减少到514瓶，使用的硫酸镁总瓶数从1574瓶减少到193瓶，但围产期结局，如早产率、新生儿体重和NICU住院率在两组之间没有差异。先兆早产方案变更前后早产发生率无显著变化。由于减少保胎药物的给定剂量并不影响分娩时间和新生儿结局，因此应限制先兆早产患者的长期保胎，以防止对母体和胎儿的不良副作用。
Aim: The aim of this study was to evaluate the effect of long-term use of tocolytic agents to prevent preterm delivery and improve perinatal outcome.Methods: A historical cohort study was performed in a single perinatal center. The maternal characteristics, frequency of preterm labor and prescribed dose of tocolytic agents were compared before and after changing the management protocol for threatened premature delivery.Results: A total of 1548 deliveries were carried out before changing the protocol for the use of tocolytic agents for threatened premature delivery and 1444 deliveries afterwards. There was no significant difference in the maternal characteristics before and after the revision except for maternal age. The total number of ritodrine hydrochloride ampules used was reduced from 4654 to 514, and the total vials of magnesium sulfate used were reduced from 1574 to 193, but perinatal outcomes, such as rate of preterm birth, neonatal weight, and rate of NICU hospitalization were not different between the groups.Conclusion: There was no significant change in the frequency of preterm delivery before and after changing of the protocol for threatened premature delivery. Because a decrease in the given dose of tocolytic agents did not affect the timing of delivery and neonatal outcomes, long-term tocolysis in patients with threatened premature delivery should be restricted to prevent maternal and fetal adverse side-effects.