Qualitative assessment of pica experienced by frequent blood donors.
Qualitative assessment of pica experienced by frequent blood donors.
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DOI：
10.1111/trf.13981
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发表时间：
2017-04
期刊：
影响因子：
2.9
通讯作者：
Mast AE
中科院分区：
文献类型：
--
作者：
Chansky MC;King MR;Bialkowski W;Bryant BJ;Kiss JE;D'Andrea P;Cable RG;Spencer BR;Mast AE
PICA，即强制食用冰或其他非营养物质，与铁缺乏有关，铁缺乏是频繁献血的常见负面后果。正因为如此，献血者，如那些参与减少缺铁战略(STRIDE)研究的人，是探索异食癖和缺铁的理想人群。STRIDE是一项为期两年的干预试验，旨在评估铁补充对缓解频繁献血者铁缺乏的有效性。受试者完成了基线和后续调查问卷，其中包括有关异食癖症状的问题。对其中14名报告了异食癖症状的受试者和8名假定对照(随意咀嚼冰块)的受试者进行了深入的电话采访，以更深入地了解异食癖症状及其对日常生活的影响，并最终确定是否存在异食癖。在14名报告症状的受试者中，有5人确诊为PICA，在8名对照组中有2人确诊。基于问卷的结果分类错误归因于对面谈期间发现的几种异食癖症状的评估不充分。将受试者在整个Stride过程中重复测量的定量铁与受试者最终判定的异食癖状态进行比较，发现异食癖的发展与铁状态恶化之间存在正相关关系；而在异食癖症状缓解的人中发现相反的关系。对异食癖症状问题的不断改进将使经常献血的人能够快速和准确地检测出异食癖，并确认用补铁剂成功治疗。
Pica, the compulsive consumption of ice or other nonnutritious substances, is associated with iron deficiency, a common negative consequence of frequent blood donation. Because of this, blood donors, such as those participating in the Strategies to Reduce Iron Deficiency (STRIDE) study, are an ideal population to explore pica and iron deficiency. STRIDE was a 2-year intervention trial to assess the effectiveness of iron supplementation for mitigating iron deficiency in frequent blood donors. Subjects completed baseline and follow-up questionnaires that included questions about pica symptoms. In-depth telephone interviews were conducted with 14 of these subjects reporting pica symptoms and eight presumed controls (casual ice chewers) to gain a deeper understanding of pica symptoms and their impact on daily life and to make a final determination on the presence of pica. Pica was confirmed in five of the 14 subjects reporting symptoms and in two of eight controls. Outcome misclassification based on the questionnaire was attributed to inadequate assessment of several pica symptoms identified during the interview. Comparison of subjects’ repeated quantitative iron measurements taken throughout STRIDE with subjects’ final adjudicated pica status revealed a positive relationship between development of pica and worsening iron status; the opposite was found in those whose pica symptoms resolved. Continued refinement of pica symptom questions will allow for rapid and accurate detection of pica in frequent blood donors and confirmation of successful treatment with iron supplements.