Effect of chronic substance abuse on the neuropsychological performance of intravenous drug users with a high prevalence of HIV-1 seropositivity.
Effect of chronic substance abuse on the neuropsychological performance of intravenous drug users with a high prevalence of HIV-1 seropositivity.
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慢性药物滥用对 HIV-1 血清阳性率高的静脉注射吸毒者神经心理表现的影响。
DOI：
10.1093/oxfordjournals.aje.a116446
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发表时间：
1992
影响因子：
5
通讯作者：
McArthur,JC
中科院分区：
文献类型：
--
作者：
Concha,M;Graham,NM;Muñoz,A;Vlahov,D;Royal3rd,W;Updike,M;Nance-Sproson,T;Selnes,OA;McArthur,JC
关于 1 型人类免疫缺陷病毒 (HIV-1) 感染早期无症状阶段静脉吸毒者认知表现的数据有限。 1988 年至 1990 年间，马里兰州巴尔的摩市艾滋病与静脉注射体验 (ALIVE) 关联研究的 151 名参与者每半年接受一次神经心理学评估。该分析的重点是药物滥用史是否影响神经心理学测试表现。基线时，102 名参与者的 HIV-1 血清呈阳性，且没有获得性免疫缺陷综合症，49 名参与者的血清呈阴性。进行多变量分析，调整重复结果测量的相关性，以确定神经心理功能的预测因子。报告的过去使用大麻、海洛因、可卡因、巴比妥类药物和酒精的频率的影响与测试成绩没有统计相关性。年龄和教育程度是测试成绩最重要的预测因素，大多数测试都观察到显着的练习效果。在调整年龄、教育程度、实践效果和药物使用频率后，随着时间的推移，神经心理学表现不会因 HIV-1 血清状态而变化。总体而言，在排除急性中毒个体后，吸毒和饮酒的频率以及 HIV-1 血清阳性均不会显着影响 1 年期间的神经心理学测试表现。Am J Epidemiol1992； 136：1338–48。
Limited data are available on cognitive performance in populations of intravenous drug users during the early, asymptomatic stages of human immunodeficiency virus type 1 (HIV-1) infection. Between 1988 and 1990, 151 participants from the AIDS Link to Intravenous Experience (ALIVE) Study in Baltimore, Maryland, were evaluated neuropsychologically on a semiannual basis. This analysis focused on whether history of substance abuse influenced neuropsychological test performance. At baseline, 102 participants were HIV-1-seropositives who were free of acquired immunodeficiency syndrome and 49 participants were seronegative. Multivariate analyses, adjusting for correlation of repeated outcome measures, were conducted to determine predictors of neuropsychological functioning. Effects of the frequency of reported past use of marijuana, heroin, cocaine, barbiturates, and alcohol were not statistically associated with performance on the tests. Age and education were the most important predictors of test performance, and a significant practice effect was observed for most measures. After adjustment for age, education, the practice effect, and frequency of drug use, neuropsychological performance over time did not vary by HIV-1 serostatus. Overall, after acutely intoxicated individuals were excluded, neither frequency of drug and alcohol use nor HIV-1 seropositivity significantly influenced neuropsychological test performance over a 1-year period.Am J Epidemiol1992; 136: 1338–48.