Intragastric infusion of glucose enhances the rewarding effect of sorbitol fatty acid ester ingestion as measured by conditioned place preference in mice
Intragastric infusion of glucose enhances the rewarding effect of sorbitol fatty acid ester ingestion as measured by conditioned place preference in mice
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DOI：
10.1016/j.physbeh.2009.12.018
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发表时间：
2010-03-30
影响因子：
2.9
通讯作者：
Fushiki, Tohru
中科院分区：
文献类型：
--
作者：
Matsumura, Shigenobu;Yoneda, Takeshi;Fushiki, Tohru
我们研究了在进食过程中使用条件位置偏好（CPP）测试诱导奖励效应的物质。尽管小鼠对低能量脂肪替代品山梨醇脂肪酸酯和低浓度亚油酸溶液表现出高亲和力，但在CPP测试中，它们对自愿摄入脂肪替代品没有表现出位置偏好。然而，在CPP的条件反射过程中，在摄入脂肪替代品之前立即灌胃玉米油，测试小鼠表现出位置偏好。同样，葡萄糖、半乳糖和糊精灌胃也可诱导CPP；然而，果糖、甘露糖和一种非代谢碳水化合物却没有。这些结果表明，玉米油和葡萄糖在诱导CPP方面具有相同的摄食后效应，并且碳水化合物的结构特异性影响摄食后效应。(C) 2009爱思唯尔公司版权所有。
We investigated substances that induce a rewarding effect during the postingestive process using the conditioned place preference (CPP) test. Although mice showed high affinity for a low-energy fat substitute sorbitol fatty acid esters and low-concentration linoleic acid solution they did not exhibit a place preference toward a voluntary intake of fat substitute in the CPP test. However, during a conditioning session of CPP that involved intragastric administration of corn oil immediately before the intake of the fat substitute, the test mice displayed a place preference. Similarly, intragastric administration of glucose, galactose, and dextrin also induced CPP; however, fructose, mannose, and a nonmetabolized carbohydrate did not. These results suggest that administration of corn oil and glucose has the same postingestive effect with regard to inducing CPP and that the structural specificity of carbohydrates influences the postingestive effect. (C) 2009 Elsevier Inc. All rights reserved.