Rhodium(III)-Catalyzed C-H Activation: An Oxidative Intramolecular Heck-Type Reaction Directed by a Carboxylic Acid.
Rhodium(III)-Catalyzed C-H Activation: An Oxidative Intramolecular Heck-Type Reaction Directed by a Carboxylic Acid.
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DOI：
10.1055/s-0034-1381006
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发表时间：
2015-07
期刊：
影响因子：
--
通讯作者：
Rovis T
中科院分区：
文献类型：
--
作者：
Davis TA;Wang C;Rovis T
羧酸有效地指导C-H活化铑（III）催化的分子内heck型反应。催化量的Cu(OAc)2被用作外部氧化剂，氧可能作为终端氧化剂。此外，发现一种新的缺电子的RhIII催化剂在某些底物上比[RhCp*Cl2]2更有效。各种复杂的二氢苯并呋喃、二氢苯并吡喃和其他易于进一步功能化的化合物现在可以通过相对温和的反应条件获得。
Carboxylic acids effectively direct C-H activation for Rhodium(III)-catalyzed intramolecular Heck-type reactions. A catalytic amount of Cu(OAc)2 is used as the external oxidant with oxygen likely acting as the terminal oxidant. Additionally, a novel electron-deficient RhIII catalyst was found to be more effective that [RhCp*Cl2]2 with some substrates. A wide variety of complex dihydrobenzofurans, dihydrobenzopyrans, and other bicycles that can be easily further functionalized are now accessible through relatively mild reaction conditions.