Neural control of breathing: insights from genetic mouse models
Neural control of breathing: insights from genetic mouse models
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DOI：
10.1152/japplphysiol.01266.2007
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发表时间：
2008-05-01
影响因子：
3.3
通讯作者：
Gallego, J.
中科院分区：
文献类型：
--
作者：
Gaultier, C.;Gallego, J.
最近的研究描述了突变新生小鼠的体内通气表型，该突变新生小鼠对参与呼吸神经元网络组织和发育的基因进行了有针对性的删除。全身流量气压体积描记法是研究不受约束的新生小鼠的首选无创方法。呼吸暂停的呼吸模式异常发生在缺乏参与节律发生的发育和调节的基因的突变新生小鼠中。对高碳酸血症和/或缺氧的通气反应缺陷的研究有助于识别与氧气和二氧化碳化学敏感性有关的基因。对突变新生小鼠和人类的联合研究揭示了遗传决定的呼吸控制异常的发病机制，例如先天性中枢性通气不足综合征、雷特综合征和普瑞德威利综合征。小鼠模型的开发开辟了人类呼吸控制疾病新疗法的研究领域。
Recent studies described the in vivo ventilatory phenotype of mutant newborn mice with targeted deletions of genes involved in the organization and development of the respiratory-neuron network. Whole body flow barometric plethysmography is the noninvasive method of choice for studying unrestrained newborn mice. Breathing-pattern abnormalities with apneas occur in mutant newborn mice that lack genes involved in the development and modulation of rhythmogenesis. Studies of deficits in ventilatory responses to hypercapnia and/or hypoxia helped to identify genes involved in chemosensitivity to oxygen and carbon dioxide. Combined studies in mutant newborn mice and in humans have shed light on the pathogenesis of genetically determined respiratorycontrol abnormalities such as congenital central hypoventilation syndrome, Rett syndrome, and Prader-Willi syndrome. The development of mouse models has opened up the field of research into new treatments for respiratory-control disorders in humans.