Drug Development Digital Twins for Drug Discovery, Testing and Repurposing: A Schema for Requirements and Development.
Drug Development Digital Twins for Drug Discovery, Testing and Repurposing: A Schema for Requirements and Development.
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DOI：
10.3389/fsysb.2022.928387
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发表时间：
2022-01-01
期刊：
影响因子：
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通讯作者：
Cockrell, Chase
中科院分区：
文献类型：
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作者：
An, Gary;Cockrell, Chase
医学数字双胞胎的概念、发展和实施引起了人们的极大兴趣。这种兴趣导致了人们对什么构成医学数字孪生兄弟的广泛看法。这篇展望文章将提供1)描述工业数字双胞胎的基本特征，数字双胞胎概念的来源，2)挑战医疗数字双胞胎实施的生物学方面，3)如何定义特定的医疗数字双胞胎项目的示意图计划，以及4)该示意图计划内针对特定类型的医疗数字双胞胎的示例描述，该类型的医疗数字双胞胎旨在药物发现、测试和再利用，药物开发数字双胞胎(DDDT)。
There has been a great deal of interest in the concept, development and implementation of medical digital twins. This interest has led to wide ranging perceptions of what constitutes a medical digital twin. This Perspectives article will provide 1) a description of fundamental features of industrial digital twins, the source of the digital twin concept, 2) aspects of biology that challenge the implementation of medical digital twins, 3) a schematic program of how a specific medical digital twin project could be defined, and 4) an example description within that schematic program for a specific type of medical digital twin intended for drug discovery, testing and repurposing, the Drug Development Digital Twin (DDDT).