Inverse correlation between Flt3 and PU.1 expression in acute myeloblastic leukemias
Inverse correlation between Flt3 and PU.1 expression in acute myeloblastic leukemias
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DOI：
10.1016/j.leukres.2005.07.015
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发表时间：
2006-06-01
影响因子：
2.7
通讯作者：
Sasaki, T
中科院分区：
文献类型：
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作者：
Inomata, M;Takahashi, S;Sasaki, T
Flt3 的过度表达在急性髓细胞白血病 (AML) 中普遍存在，在白血病发生中发挥作用，而 PU.1 表达的减少会在小鼠模型中诱导 AML。因此，我们推测这两个因素之间存在反比关系。为了澄清这一点，我们测量了 24 个原发性 AML 标本中 Flt3 和 PU.1 的表达水平。结果，Flt3 和 PU.1 之间存在显着负相关（r=-0.43，p < 0.05）。此外，我们发现 flt3 基因启动子受到 PU.1 过表达的抑制，表明 PU.1 是 flt3 基因启动子的潜在抑制因子。 (c) 2005 Elsevier Ltd. 保留所有权利。
Over-expression of the Flt3 is prevalent in acute myeloblastic leukemia (AML), playing a role in leukemogenesis while decreased expression of PU.1 induces AML in mice model. Therefore, we speculated that there is an inverse relationship between these two factors. To clarify this, we measured the expression level of Flt3 and PU.1 in 24 primary AML specimens. As a result, there is a significant negative correlation between Flt3 and PU.1 (r=-0.43, p < 0.05). Furthermore, we revealed that flt3 gene promoter is suppressed by the over-expression of PU.1, suggesting that PU.1 is a potential suppressor of flt3 gene promoter. (c) 2005 Elsevier Ltd. All rights reserved.