The increased accumulation of [18F]fluorodeoxyglucose in untreated prostate cancer
The increased accumulation of [18F]fluorodeoxyglucose in untreated prostate cancer
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DOI：
10.1093/jjco/29.12.623
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发表时间：
1999-12-01
影响因子：
2.4
通讯作者：
Okada, K
中科院分区：
文献类型：
--
作者：
Oyama, N;Akino, H;Okada, K
背景资料：[F-18]氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）与组织病理学分级、临床分期和血清前列腺特异性抗原（PSA）水平比较，评价FDG-PET在前列腺癌诊断和鉴别诊断中的临床价值。前瞻性研究了44例经组织学证实的前列腺癌患者和5例良性前列腺增生（BPH）对照者的FDG-结果：肉眼观察，28例前列腺癌患者FDG积聚阳性（敏感性64%），而对照组均为阴性。3例淋巴结转移患者的FDG-PET检查未见盆腔内高密度FDG-PET。12例多发性骨转移患者经99 m-HMDP骨显像检查，9例（75%）骨转移灶内FDG-PET显示中~高密度。定量分析显示，前列腺癌的FDG蓄积显著高于BPH，且肿瘤的FDG摄取倾向于随着组织学Gleason分级的升高而升高。有淋巴结和/或骨转移的肿瘤FDG摄取明显高于局限期肿瘤。然而，PSA和FDG摄取在前列腺癌之间的相关性是非常弱的临床relevance.Conclusions：虽然FDG-PET是不够敏感，以检测前列腺癌在临床上使用，这表明，前列腺癌的葡萄糖代谢往往是较高的肿瘤的晚期患者。
Background: To evaluate the clinical usefulness of [F-18]fluorodeoxyglucose positron emission tomography (FDG-PET) compared with histopathological grading, clinical stage and serum prostatic specific antigen (PSA) level in the detection and characterization of prostate cancer.Methods: Forty-four patients with histologically proven prostate cancer and five control subjects with benign prostatic hyperplasia (BPH) were prospectively investigated with FDG-PET prior to treatment.Results: By visual inspection, FDG accumulation was positive in 28 patients with prostate cancer (sensitivity 64%), whereas all were negative in the control group. FDG-PET in three patients with lymph node metastases did not show any high intrapelvic accumulations corresponding to metastatic sites, Among 12 patients with multiple bone metastases which were detected with 99m-HMDP bone scintigraphy, nine (75%) showed moderate to high FDG, accumulation at the sites of bone metastases. Quantitatively, FDG accumulation in prostate cancer was significantly higher than in BPH and there was a tendency for FDG uptake of tumors to be higher with higher histological Gleason grades. Furthermore, FDG uptake in tumors with lymph node and/or bone metastasis was significantly higher than that of localized stages. However, the correlation between PSA and FDG uptake in the prostate cancer was very weak for clinical relevance.Conclusions: Although FDG-PET was not sensitive enough to detect prostate cancer in clinical use, it is suggested that glucose metabolism in prostate cancer tended to be higher in patients with tumors of advanced stages.