Intrapleural streptokinase for the treatment of complicated parapneumonic effusion and empyema in 2 newborns
Intrapleural streptokinase for the treatment of complicated parapneumonic effusion and empyema in 2 newborns
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DOI：
10.1016/j.jpedsurg.2012.07.034
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发表时间：
2012-10-01
影响因子：
2.4
通讯作者：
Dilmen, Ugur
中科院分区：
文献类型：
--
作者：
Yigit, Avidan Kizilelma;Yilmaz, Yavuz;Dilmen, Ugur
复杂性胸腔积液的传统一线治疗，如肋间置管引流和抗生素治疗，可能会失败，因为粘稠的液体和多个胸膜腔室。胸膜腔内纤溶治疗是一种非侵入性治疗选择。在这篇报告中，我们提出成功地使用胸膜内链激酶治疗2例新生儿复杂性胸膜旁积液和脓胸。链激酶胸腔内溶栓治疗是一种安全有效的选择性治疗方法，即使在新生儿并发胸膜旁积液和脓胸的情况下也有明显的获益，因此，它可以避免外科干预。(C)2012 Elsevier Inc. All rights reserved.
The management of complicated parapneumonic effusions by conventional first-line treatment with closed intercostal tube drainage and antibiotic therapy may fail because of thick viscous fluid and multiple pleural space loculations. Intrapleural fibrinolytic treatment is a non-invasive therapeutic option. In this report, we present successful use of intrapleural streptokinase for complicated parapneumonic effusion and empyema in 2 newborns. Intrapleural fibrinolytic therapy with streptokinase appears to be a safe and effective adjunctive therapy of choice and may have significant benefit even in newborns with complicated parapneumonic effusion and empyema, and thus, it can obviate surgical intervention. (C) 2012 Elsevier Inc. All rights reserved.