Basolateral amygdala supports the maintenance of value and effortful choice of a preferred option
Basolateral amygdala supports the maintenance of value and effortful choice of a preferred option
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DOI：
10.1111/ejn.13497
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发表时间：
2017-02-01
影响因子：
3.4
通讯作者：
Izquierdo, Alicia
中科院分区：
文献类型：
--
作者：
Hart, Evan E.;Izquierdo, Alicia
众所周知，基底外侧杏仁核（BLA）与食欲行为有关，但它在质量不同的奖励（更多/更少偏好）的成本-收益选择中的作用，超出了幅度差异（更大/更小），却知之甚少。我们评估了BLA失活对努力选择行为的影响。大鼠在BLA中植入导管，并按递进比例计划训练稳定杠杆按压蔗糖颗粒。然后向大鼠介绍一种选择：同时提供食物，而它们可以为首选的蔗糖颗粒工作。在实验前，大鼠分别注射载体对照（aCSF）或巴氯芬/muscimol。与车辆相比，BLA失活导致蔗糖颗粒的杠杆压显着减少，并且食物消耗不受影响。当两种选择都可以自由获得时，失活对蔗糖颗粒的偏好没有影响。关键的是，当实验室没有同时可用的食物时，BLA失活对蔗糖颗粒的杠杆按压次数没有影响，这表明在没有选择的情况下，BLA离线的主要动机仍然是完整的。在对蔗糖颗粒进行特定饱腹感测试后，与对照组相比，BLA失活使动物对贬值不那么敏感。在我们的任务中，BLA失活的影响不是通过食欲下降、无法执行任务、食物偏好的改变或主要动机的减少来介导的。综上所述，BLA支持特定的价值和优选选项的努力选择。
The basolateral amygdala (BLA) is known to be involved in appetitive behavior, yet its role in cost-benefit choice of qualitatively different rewards (more/less preferred), beyond magnitude differences (larger/smaller), is poorly understood. We assessed the effects of BLA inactivations on effortful choice behavior. Rats were implanted with cannulae in BLA and trained to stable lever pressing for sucrose pellets on a progressive ratio schedule. Rats were then introduced to a choice: chow was concurrently available while they could work for the preferred sucrose pellets. Rats were infused with either vehicle control (aCSF) or baclofen/muscimol prior to test. BLA inactivations produced a significant decrease in lever presses for sucrose pellets compared to vehicle, and chow consumption was unaffected. Inactivation had no effect on sucrose pellet preference when both options were freely available. Critically, when lab chow was not concurrently available, BLA inactivations had no effect on the number of lever presses for sucrose pellets, indicating that primary motivation in the absence of choice remains intact with BLA offline. After a test under specific satiety for sucrose pellets, BLA inactivation rendered animals less sensitive to devaluation relative to control. The effects of BLA inactivations in our task are not mediated by decreased appetite, an inability to perform the task, a change in food preference, or decrements in primary motivation. Taken together, BLA supports the specific value and effortful choice of a preferred option.