Cannabis and cannabis extracts: greater than the sum of their parts?
Cannabis and cannabis extracts: greater than the sum of their parts?
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DOI：
10.1300/j175v01n03_08
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发表时间：
2001-01-01
期刊：
影响因子：
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通讯作者：
Russo, E. B.
中科院分区：
文献类型：
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作者：
McPartland, J. M.;Russo, E. B.
使用植物疗法的一个核心原则是草药含有许多有效成分。主要活性成分可以通过起到有益的协同作用的次要化合物来增强。其他草本成分可能会减轻主要活性成分的副作用。我们回顾了有关医用大麻及其主要活性成分Delta9-四氢大麻酚(THC)的文献。有充分证据表明，大麻中的二次化合物可能会增强THC的有益效果。草本大麻或其提取物中的其他大麻素和非大麻素化合物可能会减少THC引起的焦虑、胆碱能缺陷和免疫抑制。大麻萜类和类黄酮类还可以增加脑血流量，增强皮质活性，杀死呼吸道病原体，并提供抗炎活性。
A central tenet underlying the use of botanical remedies is that herbs contain many active ingredients. Primary active ingredients may be enhanced by secondary compounds which act in beneficial synergy. Other herbal constituents may mitigate the side effects of dominant active ingredients. We reviewed the literature concerning medical cannabis and its primary active ingredient, Delta9-tetrahydrocannabinol (THC). Good evidence shows that secondary compounds in cannabis may enhance the beneficial effects of THC. Other cannabinoid and non-cannabinoid compounds in herbal cannabis or its extracts may reduce THC-induced anxiety, cholinergic deficits and immunosuppression. Cannabis terpenoids and flavonoids may also increase cerebral blood flow, enhance cortical activity, kill respiratory pathogens and provide antiinflammatory activity.