Circulating IL-2 and IL-10 in chronic active hepatitis C with respect to the response to IFN treatment
Circulating IL-2 and IL-10 in chronic active hepatitis C with respect to the response to IFN treatment
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DOI：
10.1007/s150100070025
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发表时间：
2000-09-01
期刊：
影响因子：
7.5
通讯作者：
Uzunalimoglu, Ö
中科院分区：
文献类型：
--
作者：
Bozkaya, H;Bozdayi, AM;Uzunalimoglu, Ö
背景：干扰素治疗反应中循环免疫调节细胞因子的重要性以及干扰素治疗期间这些细胞因子在体内产生的变化尚不为人所知。我们的目的是确定治疗前血清IL-2和IL-10水平是否可以预测干扰素治疗的应答，以及治疗有效和无应答对这些细胞因子水平的影响。患者和方法：37例慢性丙型肝炎病毒感染患者(18例应答者和19例无应答者)接受干扰素-α2b治疗6个月。以丙氨酸氨基转移酶(ALT)完全正常者和丙型肝炎病毒核糖核酸(HCVRNA)缺失者为应答者，6个月后ALT升高且HCVRNA阳性者为无应答者。结果：应答者和无应答者的基因分布、ALT和HCVRNA水平相似。显著数量的慢性丙型肝炎患者(20/37=54%)IL-2水平升高，而IL-10水平与对照组无差异。在应答者和无应答者之间，基线细胞因子水平没有差异。结论：慢性丙型肝炎患者活动性肝损伤与Th1细胞因子IL-2升高有关，与Th2细胞因子IL-10无关，循环中这些细胞因子水平不能预测干扰素治疗的疗效。在干扰素治疗下，这些细胞因子的循环水平在治疗反应方面没有持续和规律的变化。
Background: The importance of circulating immunoregulatory cytokines in response to IFN treatment and the change of in vivo production of these cytokines during interferon (IFN) treatment are not well known. We aimed to determine whether pretreatment serum levels of IL-2 and IL-10 are predictive of the response to IFN treatment and to investigate if treatment response or nonresponse has any effect on the circulating levels of these cytokines.Patients and Methods: 37 patients (18 responders and 19 non-responders) with chronic hepatitis C virus (HCV) infection who received IFN-alpha 2b for 6 months were studied. Responders were defined by complete alanine aminotransferase (ALT) normalization and loss of HCV RNA as detected by bDNA assay while patients who had elevated ALT levels and positive HCV RNA after 6 months were considered as nonresponders.Results: Genotype distribution, ALT and HCV RNA levels were similar in responders and nonresponders. A significant number of patients with chronic hepatitis C (20/37 = 54%) had elevated IL-2 levels while IL-10 levels were not different from controls. No difference in baseline cytokine levels was observed between responders and non-responders. In the posttreatment serum samples some patients lost their detectable IL-2 or IL-10; some patients developed detectable cytokine levels after treatment irrespective of the treatment response.Conclusion: These results suggest that active liver injury in chronic hepatitis C is associated with increased circulating Th1 cytokine IL-2 but not with Th2 cytokine IL-10 and that circulating levels of these cytokines do not predict the response to IFN treatment. There is no constant and regular change in circulating levels of these cytokines under IFN treatment with respect to treatment response.