Using chemical biology to assess and modulate mitochondria: progress and challenges.
Using chemical biology to assess and modulate mitochondria: progress and challenges.
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DOI：
10.1098/rsfs.2016.0151
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发表时间：
2017-04-06
期刊：
影响因子：
4.4
通讯作者：
Murphy MP
中科院分区：
文献类型：
--
作者：
Logan A;Murphy MP
在过去的十年中，我们对线粒体在生物医学中的作用的理解有了很大的扩展。除了众所周知的代谢作用外，线粒体还通过产生影响细胞稳态的 ROS 和代谢物等信号以及细胞死亡和炎症等其他过程，在各种过程的信号传导中发挥着核心作用。因此，线粒体功能和功能障碍对于细胞的健康和命运至关重要。因此，人们对更好地理解和评估线粒体的许多作用非常感兴趣。此外，人们也越来越认识到线粒体是多种病理学中有希望的药物靶点。跨学科方法在化学和生物学之间的交叉应用为理解线粒体功能和评估细胞器在生物学中的作用开辟了新的机会。这项工作和由此获得的经验正在导致新型疗法的开发。在这里，我们概述了迄今为止在探索细胞器化学生物学方面所取得的进展，然后重点关注这个快速发展的领域面临的未来挑战和机遇。
Our understanding of the role of mitochondria in biomedical sciences has expanded considerably over the past decade. In addition to their well-known metabolic roles, mitochondrial are also central to signalling for various processes through the generation of signals such as ROS and metabolites that affect cellular homeostasis, as well as other processes such as cell death and inflammation. Thus, mitochondrial function and dysfunction are central to the health and fate of the cell. Consequently, there is considerable interest in better understanding and assessing the many roles of mitochondria. Furthermore, there is also a growing realization that mitochondrial are a promising drug target in a wide range of pathologies. The application of interdisciplinary approaches at the interface between chemistry and biology are opening up new opportunities to understand mitochondrial function and in assessing the role of the organelle in biology. This work and the experience thus gained are leading to the development of new classes of therapies. Here, we overview the progress that has been made to date on exploring the chemical biology of the organelle and then focus on future challenges and opportunities that face this rapidly developing field.