Genetic characterization of breast cancer and implications for clinical management.
Genetic characterization of breast cancer and implications for clinical management.
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DOI:
10.1111/j.1582-4934.2009.00906.x
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发表时间:
2009-10
影响因子:
5.3
通讯作者:
Reis-Filho JS
中科院分区:
文献类型:
--
作者:
Geyer FC;Lopez-Garcia MA;Lambros MB;Reis-Filho JS
Breast cancer is a genetic disease caused by the accumulation of mutations in neoplastic cells. In the last few years, high-throughput microarray-based molecular analysis has provided increasingly more coherent information about the genetic aberrations in breast cancer. New biomarkers and molecular techniques are slowly becoming part of the diagnostic and prognostic armamentarium available for pathologists and oncologists to tailor the therapy for breast cancer patients. In this review, we will focus on the contribution of breast cancer somatic genetics to our understanding of breast cancer biology and its impact on breast cancer patient management.
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