CLINICAL OUTCOME OF SACRAL CHORDOMA WITH CARBON ION RADIOTHERAPY COMPARED WITH SURGERY
CLINICAL OUTCOME OF SACRAL CHORDOMA WITH CARBON ION RADIOTHERAPY COMPARED WITH SURGERY
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DOI：
10.1016/j.ijrobp.2009.10.051
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发表时间：
2011-01-01
影响因子：
7
通讯作者：
Ishiguro, Naoki
中科院分区：
文献类型：
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作者：
Nishida, Yoshihiro;Kamada, Tadashi;Ishiguro, Naoki
目的：评价碳离子放射治疗（RT）与手术治疗骶骨脉络膜炎的疗效、治疗后功能、毒性和并发症。方法和材料：回顾性分析了自1990年以来接受手术（n = 10）或碳离子RT（n = 7）治疗的17例原发性骶骨脉络膜炎患者的记录，包括疾病特异性生存率、局部无复发生存率、并发症、功能性结果。应用的碳离子剂量范围从54.0 Gray当量（GyE）到73.6 GyE（中位数70.4）。结果：手术组治疗时的平均年龄为55岁，碳离子RT组为65岁。手术组的中位随访时间为76个月，碳离子RT组为49个月。5年局部无复发生存率分别为62.5%和100%，5年疾病特异性生存率分别为85.7%和53.3%。手术组6例（60%）患者的泌尿-肛门直肠功能恶化，3例患者（30%）在手术后发生了需要再次手术的术后伤口并发症，1例患者（14%）在碳离子RT后发生了术后伤口并发症。使用肌肉骨骼肿瘤协会评分系统评估的功能结果显示，55%手术组有效率为75%，碳离子组为75%。在这个评分系统中的六个因素，碳离子RT组有显着更大的分数在情感上的接受比手术group.Conclusion：碳离子RT结果在一个高的局部控制率和保存的泌尿肛门直肠功能相比，手术。(C)2011 Elsevier Inc.
Purpose: To evaluate the efficacy, post-treatment function, toxicity, and complications of carbon ion radiotherapy (RT) for sacral chordoma compared with surgery.Methods and Materials: The records of 17 primary sacral chordoma patients treated since 1990 with surgery (n = 10) or carbon ion RT (n = 7) were retrospectively analyzed for disease-specific survival, local recurrence-free survival, complications, and functional outcome. The applied carbon ion dose ranged from 54.0 Gray equivalent (GyE) to 73.6 GyE (median 70.4).Results: The mean age at treatment was 55 years for the surgery group and 65 years for the carbon ion RT group. The median duration of follow-up was 76 months for the surgery group and 49 months for the carbon ion RT group. The local recurrence-free survival rate at 5 years was 62.5% for the surgery and 100% for the carbon ion RT group, and the disease-specific survival rate at 5 years was 85.7% and 53.3%, respectively. Urinary-anorectal function worsened in 6 patients (60%) in the surgery group, but it was unchanged in all the patients who had undergone carbon ion RT. Postoperative wound complications requiring reoperation occurred in 3 patients (30%) after surgery and in 1 patient (14%) after carbon ion RT. The functional outcome evaluated using the Musculoskeletal Tumor Society scoring system revealed 55% in the surgery group and 75% in the carbon ion RT group. Of the six factors in this scoring system, the carbon ion RT group had significantly greater scores in emotional acceptance than did the surgery group.Conclusion: Carbon ion RT results in a high local control rate and preservation of urinary-anorectal function compared with surgery. (C) 2011 Elsevier Inc.