Soluble P-selectin as a marker of in vivo platelet activation
Soluble P-selectin as a marker of in vivo platelet activation
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DOI：
10.1016/j.cca.2008.09.018
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发表时间：
2009-01-01
影响因子：
5
通讯作者：
Guadagni, Fiorella
中科院分区：
文献类型：
--
作者：
Ferroni, Patrizia;Martini, Francesca;Guadagni, Fiorella
背景：血小板是循环中sP-选择素的主要来源。在许多动脉粥样硬化性血栓性疾病中发现这种蛋白水平升高。因此，我们研究了sP-选择素的剂量是否可以反映有心血管疾病危险因素的患者的血小板功能，以及阿司匹林治疗是否可以调节其水平。方法：对152例门诊患者的血浆sP-选择素水平和光透射性血小板聚集率(LTA)进行分析。结果：在肾上腺素(p=0.022)和花生四烯酸(p=0.006)的作用下，sP-选择素与Mx%LtA显著相关(p=0.006)，与胶原滞后期(p=0.016)显著相关。多元回归分析显示，P-选择素水平的唯一预测因子是血小板数量(P<；0.001)和含胶原蛋白滞后期(P<0.05)。
Background: Platelets are the major source of circulating sP-selectin. Elevated levels of this protein have been found in many atherothrombotic disorders. Thus, we investigated whether sP-selectin dosage might reflect platelet function in patients with risk factors for or with established cardiovascular diseases and whether its levels can be modulated by aspirin therapy.Methods: Plasma sP-selectin levels and light transmission platelet aggregometry (LTA) were analyzed in 152 outpatients. The effects of a 6-month aspirin therapeutic course on sP-selectin levels and LTA in 51 consecutive patients have been also investigated.Results: Significant correlations were observed between sP-selectin and Mx% LTA in response to epinephrine (p = 0.022) and arachidonic acid (p = 0.006), or between sP-selectin and collagen lag-phase (p = 0.016). Multiple regression analysis showed that the only predictors of sP-selectin levels were platelet number (p < 0.001) and collagen-incluced lag-phase (p