Comparison of once-daily, niacin extended/release/lovastatin with standard doses of atorvastatin and simvastafin (The Advicor Versus Other Cholesterol-Modulating Agents Trial Evaluation [ADVOCATE])

Comparison of once-daily, niacin extended/release/lovastatin with standard doses of atorvastatin and simvastafin (The Advicor Versus Other Cholesterol-Modulating Agents Trial Evaluation [ADVOCATE])
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DOI:
10.1016/s0002-9149(03)00007-9
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发表时间:
2003-03-15
影响因子:
2.8
通讯作者:
Crouse, JR
Crouse, JR
中科院分区:
医学3区
文献类型:
--
作者:
Bays, HE;Dujovne, CA;Crouse, JR

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This study compared the relative efficacy of a once-daily niacin extended-release (ER)/Iovostatin fixed-dose combination with standard doses of atorvastatin or simvastatin, with a special emphasis on relative starting doses. Subjects (n = 315) with elevated low-density lipoprotein (LDL) cholesterol and decreased high-density lipoprotein (HDL) cholesterol blood levels (defined as LDL cholesterol blood levels greater than or equal to160 mg/dl without coronary artery disease, or greater than or equal to130 mg/dl if coronary artery disease was present, and HDL cholesterol