Increased vascular responsiveness in lungs of rats with pulmonary hypertension induced by monocrotaline pyrrole.
Increased vascular responsiveness in lungs of rats with pulmonary hypertension induced by monocrotaline pyrrole.
复制标题
野百合碱吡咯诱导的肺动脉高压大鼠肺部血管反应性增加。
DOI：
10.1164/arrd.1985.131.1.46
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Roth,RA
中科院分区：
文献类型：
--
作者：
Hilliker,KS;Roth,RA
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Monocrotaline (MCT) is a natural product that causes pulmonary hypertension in rats after metabolic activation to a pyrrole form (MCTP). To examine the vascular reactivity of the pulmonary bed, blood-perfused isolated lungs from MCTP- or vehicle-treated rats were challenged with angiotensin II (All) and 5-hydroxytryptamine (5HT), and the resultant increases in perfusion pressure were measured. Fourteen days after a single exposure, the pressor responses to All (0.25 or 0.50 µg) and 5 HT (12.5 to 50 μg) were approximately 3 times as great in isolated lungs of MCTP-treated rats as in those of control rats. When examined 7 days after exposure, the response to 25 µg 5HT but not to 0.25 µg All was enhanced by MCTP; MCT is known to decrease 5HT uptake by pulmonary capillary endothelial cells. Imipramine, a 5HT uptake inhibitor, did not alter the vascular responses to 25 µg 5HT in lungs from either control or MCTP-treated rats. The increased responsiveness of the pulmonary vasculature to All and 5HT after MCTP exposure could play a role in the development and/or maintenance of pulmonary hypertension in this rat model.