Antipyrine kinetics in liver disease and liver transplantation.
Antipyrine kinetics in liver disease and liver transplantation.
复制标题
肝病和肝移植中的安替比林动力学。
DOI：
10.1038/clpt.1986.57
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发表时间：
1986
影响因子：
6.7
通讯作者：
Starzl,TE
中科院分区：
文献类型：
--
作者：
Mehta,MU;Venkataramanan,R;Burckart,GJ;Ptachcinski,RJ;Yang,SL;Gray,JA;VanThiel,DH;Starzl,TE
研究了7名正常受试者、10名肝病患者和13名接受肝移植的临床稳定患者的安替比林动力学。对5例患者进行肝移植前后的研究。用高效液相色谱法测定口服给药后唾液中的安替比林浓度。肝病患者的安替比林t / 2明显长于肝移植患者和正常人（P < 0.05）。安替比林清除率在肝移植患者与正常人之间无显著差异，但在肝病患者中明显降低（P < 0.05）。在肝移植前后研究的5例患者中，肝移植后安替比林清除率显著升高（P < 0.05），其清除率显著降低（P < 0.05）。这些结果表明肝移植提高了肝病患者的药物代谢能力，临床稳定患者肝移植后肝脏的氧化代谢能力与正常人相近。临床药理学和治疗学（1986）39,372-377；doi: 10.1038 / clpt.1986.57
Antipyrine kinetics were studied in seven normal subjects, 10 patients with liver disease, and 13 clinically stable patients who received a liver transplant. Five patients were studied both before and after liver transplantation. Antipyrine concentrations in saliva after oral dosing were measured by HPLC. The antipyrine t½was significantly longer (P < 0.05) in patients with liver disease than in patients undergoing liver transplantation and normal subjects. Antipyrine clearance was not significantly different between patients undergoing liver transplantation and normal subjects, but it was significantly reduced (P < 0.05) in patients with liver disease. In five patients who were studied before and after liver transplantation, there was a significant (P < 0.05) increase in the antipyrine clearance and a marked reduction in its t½after liver transplantation. These results indicate that liver transplantation improves the drug metabolizing ability of patients with liver disease and that the oxidative metabolizing capacity of the liver in clinically stable patients after liver transplantation is similar to that of normal subjects.Clinical Pharmacology and Therapeutics(1986)39,372–377; doi:10.1038/clpt.1986.57