High sensitivity, specificity and predictive value of the connective tissue disease screening questionnaire among urban African-American women
High sensitivity, specificity and predictive value of the connective tissue disease screening questionnaire among urban African-American women
复制标题
DOI：
10.1191/0961203305lu2227oa
复制
发表时间：
2005-01-01
期刊：
影响因子：
2.6
通讯作者：
Fraser, PA
中科院分区：
文献类型：
--
作者：
Karlson, EW;Costenbader, KH;Fraser, PA
结缔组织疾病筛查问卷（CSQ）用于筛查SLE和其他CTD人群，已在以白人为主的医院对照人群中得到验证。我们的目的是测试的性能特点CSQ在城市，主要是非洲裔美国人的人口。CSQ通过访谈管理的环境危险因素和SLE的研究招募的妇女，包括99例SLE患者的医疗记录审查和202例健康对照从社区招募。总体而言，88%的受试者为非洲裔，6%为西班牙裔，4%为非西班牙裔高加索人。对照组比病例组更可能报告非洲遗传（91%对82%，P = 0.001）。诊断SLE的敏感性为88%，特异性为91%。在这项研究中，SLE的患病率为33%，阳性CSQ的预测值为82%，阴性CSQ的预测值为94%。与以医院为基础的对照组相比，在以社区为基础的对照组的城市，主要是非洲裔美国人人群中，CSQ对SLE的敏感性略低，但特异性更高。这些结果表明，CSQ有足够的敏感性和特异性，可用于人口研究，以筛选非裔美国妇女SLE。Lupus（2005）14，832-836.
The Connective Tissue Disease Screening Questionnaire (CSQ), developed to screen populations for SLE and other CTDs, has been validated in a predominantly Caucasian population with hospital-based controls. We aimed to test the performance characteristics of the CSQ in an urban, predominantly African-American population. The CSQ was administered by interview to women recruited for a study of environmental risk factors and SLE, including 99 cases with SLE validated by medical record review and 202 healthy controls recruited from the community. Overall, 88% of subjects had African heritage, 6% were Hispanic and 4% were non-Hispanic Caucasian. Controls were more likely to report African heritage than cases (91% versus 82%, P = 0.001). Sensitivity for detecting SLE was 88% and specificity was 91%. In this study, where the prevalence of SLE was 33%, predictive value of a positive CSQ was 82% and predictive value of a negative CSQ was 94%. The CSQ has slightly lower sensitivity but greater specificity for SLE in an urban, predominantly African-American population with community-based controls compared with a Caucasian population with hospital-based controls. These results suggest that the CSQ has adequate sensitivity and specificity and could be used in population studies to screen African-American women for SLE. Lupus(2005)14, 832-836.