Weight loss and the renin-angiotensin-aldosterone system
Weight loss and the renin-angiotensin-aldosterone system
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DOI：
10.1161/01.hyp.0000154361.47683.d3
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发表时间：
2005-03-01
期刊：
影响因子：
8.3
通讯作者：
Sharma, AM
中科院分区：
文献类型：
--
作者：
Engeli, S;Bohnke, J;Sharma, AM
肾素-血管紧张素-醛固酮系统与肥胖相关的高血压有因果关系。我们研究了肥胖和体重减轻对更年期女性循环和脂肪组织肾素-血管紧张素-醛固酮系统的影响。分析血样中的血管紧张素原、肾素、醛固酮、血管紧张素转换酶活性和血管紧张素 II。在脂肪组织活检样本中，我们分析了血管紧张素原、肾素、肾素受体、血管紧张素转换酶和血管紧张素 II 1 型受体的基因表达。肥胖女性 (n = 19) 的循环血管紧张素原、肾素、醛固酮和血管紧张素转换酶高于瘦女性 (n = 19)，而脂肪组织中血管紧张素原基因表达较低。 17 名女性成功参与了为期 13 周的减肥方案，每日减少了 600 kcal 的热量摄入。体重降低了 5%，血管紧张素原水平降低了 27%，肾素降低了 43%，醛固酮降低了 31%，血管紧张素转换酶活性降低了 12%，脂肪组织中血管紧张素原表达降低了 20%（所有 P < 0.05）。血浆血管紧张素原下降与腰围下降高度相关（r = 0.74；P < 0.001）。体重和肾素-血管紧张素-醛固酮系统的降低伴随着收缩压动态血压降低7-mm Hg。这些数据表明，体重减轻 5% 可以导致血浆和脂肪组织中的肾素-血管紧张素-醛固酮系统显着减少，这可能有助于降低血压。
The renin- angiotensin- aldosterone system has been causally implicated in obesity- associated hypertension. We studied the influence of obesity and weight reduction on the circulating and adipose tissue renin- angiotensin- aldosterone system in menopausal women. Blood samples were analyzed for angiotensinogen, renin, aldosterone, angiotensin-converting enzyme activity, and angiotensin II. In adipose tissue biopsy samples, we analyzed angiotensinogen, renin, renin- receptor, angiotensin- converting enzyme, and angiotensin II type- 1 receptor gene expression. Obese women ( n = 19) had higher circulating angiotensinogen, renin, aldosterone, and angiotensin- converting enzyme than lean women ( n = 19), and lower angiotensinogen gene expression in adipose tissue. Seventeen women successfully participated in a weight reduction protocol over 13 weeks to reduce daily caloric intake by 600 kcal. Body weight was reduced by - 5%, as were angiotensinogen levels by - 27%, renin by - 43%, aldosterone by - 31%, angiotensin- converting enzyme activity by - 12%, and angiotensinogen expression by - 20% in adipose tissue ( all P < 0.05). The plasma angiotensinogen decrease was highly correlated with the waist circumference decline ( r = 0.74; P < 0.001). Weight and renin- angiotensin- aldosterone system reductions were accompanied by a - 7- mm Hg reduced systolic ambulatory blood pressure. These data suggest that a 5% reduction in body weight can lead to a meaningfully reduced renin- angiotensin- aldosterone system in plasma and adipose tissue, which may contribute to the reduced blood pressure.