Nicorandil can induce severe oral ulceration.

Nicorandil can induce severe oral ulceration.
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尼可地尔可诱发严重的口腔溃疡。

DOI：
10.1067/moe.2001.110306
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发表时间：
2001
期刊：
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics
影响因子：
--
通讯作者：
S. Porter
S. Porter
中科院分区：
--
文献类型：
--
作者：
C. Scully;A. M. Azul;A. Crighton;D. Felix;A. Field;S. Porter

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目的 提高医生和牙医对尼可地尔是重度口腔溃疡潜在诱导剂的认识。 研究设计 本研究纳入了来自3个欧洲国家的9例新发溃疡病例。 结果 开始尼可地尔治疗后9个月内发生口腔溃疡，停药后1个月内溃疡消退。其他上皮细胞未见病变。 结论 用于心血管疾病患者护理的许多药物可引起口服不良反应。尼可地尔是一种新的钾通道激活剂，在一些国家用于治疗心绞痛，在一些患者中会导致持续性溃疡性口腔炎。
OBJECTIVE To increase physicians' and dentists' awareness that nicorandil is a potential inducer of severe mouth ulceration. STUDY DESIGN Nine new cases of ulceration from 3 European countries were included in this study. RESULTS Oral ulceration developed within 9 months of beginning nicorandil therapy, and ulcers resolved within 1 month of withdrawal of the drug. No lesions developed on other epithelia. CONCLUSIONS A number of drugs used in the care of patients with cardiovascular disease can cause oral adverse effects. Nicorandil, a new potassium-channel activator used in some countries to treat angina pectoris, precipitates persistent ulcerative stomatitis in some patients.