Hippocampal magnetization transfer ratio at 3T: validation of automated postprocessing and comparison of quantification metrics.
Hippocampal magnetization transfer ratio at 3T: validation of automated postprocessing and comparison of quantification metrics.
复制标题
3T 时的海马磁化传递比：自动后处理的验证和量化指标的比较。
DOI：
10.1111/j.1552-6569.2011.00697.x
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Wu,Ying
中科院分区：
文献类型：
--
作者：
Sidharthan,Shawn;Hutten,Ryan;Glielmi,Christopher;Du,Hongyan;Malone,Fiona;Ragin,AnnB;Edelman,RobertR;Wu,Ying
摘要背景使用直方图分析研究海马体新型磁化传输比 (MTR) 后处理技术的可靠性，并将结果与更成熟的体积测量结果进行比较。这项研究是在健康志愿者中进行的，作为未来在阿尔茨海默氏病等进行性神经系统疾病方面的应用的先驱。方法使用定量磁共振成像 (MRI) 对 8 名健康受试者进行两次扫描，每次间隔 1 周。对每位患者的海马区域进行自动像素分析。使用组内相关系数 (ICC)、变异系数 (COV) 和仪器标准差 (ISD) 评估可靠性。结果可靠的指标为 25%、中位数、75%、峰值位置和平均方法（范围：ICC = 0.93‐.96，COV = 2.71‐3.88%，ISD 0.78‐1.01）。直方图峰值高度的 ICC 低于 0.7，COV 高于 10%。体积测量（ICC = .95‐.97，COV = 1.43‐3.39%）。 结论 对于特定 MTR 直方图指标和平均 MTR 方法，观察到出色的扫描重复性（ICC > .9，COV < 10%）。这些结果与体积法相当。未来的研究可以检验 MTR 变化先于形态变化的可能性，因为本研究表明 MTR 和海马体的体积测量都可以用作可靠的成像工具。
ABSTRACTBACKGROUNDTo investigate the reliability of a novel magnetization transfer ratio (MTR) postprocessing technique for the hippocampus using histogram analysis, and compare results to more established volumetric measurements. This study is conducted in healthy volunteers as a precursor to future applications regarding progressive neurologic diseases, such as Alzheimer's disease.METHODSEight healthy subjects were scanned twice with interval of 1 week using quantitative magnetic resonance imaging (MRI). Automated pixel‐wise analysis was performed for the hippocampal regions of each patient. Reliability was assessed using intraclass correlation coefficients (ICCs), coefficients of variation (COVs), and instrumental standard deviation (ISD).RESULTSReliable metrics were 25th percentile, median, 75th percentile, peak location, and mean approach (ranges: ICC = .93‐.96, COV = 2.71‐3.88%, ISD .78‐1.01). Histogram peak height had ICC below .7, and a COV above 10%. Volumetric measurements had (ICC = .95‐.97, COV = 1.43‐3.39%).CONCLUSIONExcellent scan‐rescan reproducibility (ICC > .9, COV < 10%) was observed for specific MTR histogram metrics and the mean MTR approach. These results are comparable to the volumetric approach. Future studies can examine the possibility that MTR changes precede morphological changes as this study suggests that both MTR and volumetric measurements of the hippocampus can be used as reliable imaging tools.