Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations.
Zygotic lethal mutations with maternal effect phenotypes in Drosophila melanogaster. II. Loci on the second and third chromosomes identified by P-element-induced mutations.
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DOI：
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发表时间：
1996-12
期刊：
影响因子：
3.3
通讯作者：
N. Perrimon;A. Lanjuin;Charles Arnold;E. Noll
中科院分区：
文献类型：
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作者：
N. Perrimon;A. Lanjuin;Charles Arnold;E. Noll
仅对X染色体进行了与特定母体效应致死表型相关的合子致死突变的筛选。为了识别常染色体上的基因座（占果蝇基因组的五分之四），我们使用常染色体“FLP-DFS”技术来筛选伯克利果蝇基因组计划建立的496个P元件诱导的突变集合。我们已经确定了64个新的基因座，其基因产物是正常卵子形成或正常胚胎发育所必需的。
Screens for zygotic lethal mutations that are associated with specific maternal effect lethal phenotypes have only been conducted for the X chromosome. To identify loci on the autosomes, which represent four-fifths of the Drosophila genome, we have used the autosomal "FLP-DFS" technique to screen a collection of 496 P element-induced mutations established by the Berkeley Drosophila Genome Project. We have identified 64 new loci whose gene products are required for proper egg formation or normal embryonic development.